Abstract: Objective: To separate and screen the effective fractions of the muskmelon fruit pedicel. Methods: With 80% ethanol extract obtained after the muskmelon fruit pedicel total extract by silica gel column in ascending order of solvent polarity separation (petroleum ether - ethyl acetate - methanol continuous elution) obtained sub-extract (petroleum ether I, ethyl acetate II, methanol III) to study the effective part capable of inducing vomiting in dogs. Special color reaction was applied to confirm the chemical property of the effective fractions of the muskmelon fruit pedicel by. Results：The ethyl acetate extract of the muskmelon fruit pedicel has the emetic effects compared with the control group (P<0.01). The effective fractions contained Cucurbitacin substances identified by special color reaction. Conclusions：The effective fractions contained. Cucurbitacin substances might be the emetic fraction in the muskmelon fruit pedicel.

Key words: the muskmelon fruit pedicel, emetic action, effective parts, silica gel column separation