Protective Effects and Mechanisms of L-carnitine in the Nervous System

Abstract

Abstract: L-carnitine is a special kind of amino acids in body tissues. It has been proved that L-carnitine has neuroprotective effects on injured brain in many studies. The neuroprotective mechanisms include improving energy metabolism，inhibiting oxidative stress，restraining inflammatory response，reducing the blood brain barrier damage，and inhibiting neuronal apoptosis. It is a compound with a broad clinical application potential. This review mainly discussed the protective effects and mechanisms of L-carnitine in the central nervous system.

Key words: L-carnitine, oxidative stress, inflammatory mediator, apoptosis

CLC Number:

R964

YAN Juan，ZHENG Mao-dong. Protective Effects and Mechanisms of L-carnitine in the Nervous System[J]. Acta Neuropharmacologica, 2015, 5(1): 45-50.

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