The Relationship Between reactive oxygen species (ROS) and activation of neutrophilic alkaline phosphatase 3 (NALP3) Inflammasome

Abstract

Abstract: Inflammatory reaction has been proved to play an important role in the cerebral ischemia/reperfusion. Inflammasomes are a family of protein complexes that were recently identified as the cellular machinery responsible for recognizing pathogen-associated molecular patterns and reacting to these through activation of inflammatory processes, such as IL1b and IL18. Among different types of inflammasomes, the neutrophilic alkaline phosphatase-3 (NALP3) inflammasome is the most studied. It is characterized as a proteolytic complex mainly composed of the neutrophilic alkaline phosphatase-3 (NALP3), the adaptor protein apoptosis-associated speck-like protein (ASC), and caspase-1. However, little is known on the molecular mechanisms that mediate its assembly and activation. Recent evidence suggests that reactive oxygen species (ROS) are produced by NALP3 activators and are essential secondary messengers signaling NALP3 inflammasome activation. This paper discussed the relationship between ROS and activation of NALP3 inflammasome.

Key words: neutrophilic alkaline phosphatase 3 (NALP3）, inflammasome, reactive oxygen species (ROS), oxidative stress

ZHANG Nan, ZHANG Xiang-jian. The Relationship Between reactive oxygen species (ROS) and activation of neutrophilic alkaline phosphatase 3 (NALP3) Inflammasome[J]. Acta Neuropharmacologica, 2013, 3(5): 50-57.

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