Research Progress of the Neroprotective Mechanism of Ischemic Postconditionining

Abstract

Abstract: Extending the thrombolysis time window and reducing reperfusion injury are problems urgently needed to be solved in ischemic cerebrovascular disease. Ischemic postconditioning provides a possible solution, which has been becoming a hot research topic. Postconditioning, which refers to a series of brief occlusions and reperfusions of the blood vessels, is conducted after ischemia/reperfusion. Postconditioning can induce organ's endogenous protective effects against ischemia reperfusion injury. This article will discuss the neuroprotective mechanism of ischemic postconditioning: reduction of brain blood flow changes after ischemia reperfusion, attenuation of ROS production and apoptosis, anti-inflammatory, and changes in pathways involved in neuronal death after stroke.

Key words: ischemic postconditioning, ischemina-reperfusion injury, neuroprotection

CLC Number:

R543

PU Ju, YAO Sheng-tao. Research Progress of the Neroprotective Mechanism of Ischemic Postconditionining[J]. ACTA NEUROPHARMACOLOGICA, 2013, 3(4): 29-34.

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