Abstract: Objective： To study the antiemetic effect of Small Pinelliae Decoction (SPD) and its mechanism. Methods： he active ingredients were extracted from TSPD(pinellia tuber:ginger=1:1) to make the granules. Cisplatin(7.5 mg·kg^-1, ip) and apomorphine(1.6 mg·kg^-1, ip) were used to prepare mink vomiting model. After 30 min of SPD (equivalent to 4.0, 1.0 g·kg^-1 crude drug) ig. adminstration, minks were administered of cisplatin or morphine to study the inhibitory effect and mechanism of SPD on the two models of vomiting. Results： SPD could inhibit acute and delayed vomiting induced by cisplatin (within 72 h) in the minks, reduce the number of retching and vomiting(P<0.01), prolong the latency to vomit (P<0.01), and inhibit the expression of NK₁ receptor in central (the area postrema) and peripheral (ileum tissue) tissues (P<0.05). SPD could also inhibit vomiting induced by apomorphine (within 6 h) (P<0.01), reduce significantly the ratio of vomiting (P<0.05) and did not affect the latency to vomit. Conclusion： SPD can inhibit vomiting induced by cisplatin and apomorphine, and its mechanism is related to the inhibition of central and peripheral NK₁ receptor expression.

Key words: Small Pinelliae Decoction（SPD）, mink, vomiting, cisplatin, apomorphine