Abstract:

Objective: To investigate the clinical study of compound Lactobacillus assisted high-dose dual regimen in the treatment of adult Helicobacter pylori (Hp) patients. Methods: 300 patients diagnosed with Hp infection in the outpatient department of Nanping First Hospital Affiliated to Fujian Medical University were randomly divided into experimental group (n=150) and control group (n=150). The experimental group was treated with high-dose dual standard regimen of Venolazan, amoxicillin and complex lactic acid bacteria. The control group was treated with high dose dual standard regimen of Venolazan and amoxicillin alone. The treatment course of the two groups was 10 days, and the eradication rate, effective rate and incidence of adverse reactions of anti-HP treatment in the two groups were evaluated. Results: The Hp eradication rate of 13C breath test, the healing of gastroscopy ulcer, the improvement of clinical symptoms of chronic gastritis and the incidence of adverse drug reactions were recorded more than 4 weeks after the end of treatment course (P>0.05). There was no statistically significant difference between the two groups (P>0.05), while the incidence of adverse drug reactions was statistically significant (P<0.05). Conclusion: The combination of compound lactic acid bacteria and high-dose combination therapy for the treatment of Hp infection may not improve the eradication rate of Hp, but it can reduce the incidence of adverse reactions to antibiotics. The variety of medication used is small, easy for patients to accept, and provides compliance, which is worthy of clinical development.

Key words: complex lactobacillus, high dose dual regimen, vonorosen, amoxicillin, combination therapy, helicobacter pylori in adults, clinical research