ACTA NEUROPHARMACOLOGICA ›› 2020, Vol. 10 ›› Issue (6): 23-26.DOI: 10.3969/j.issn.2095-1396.2020.06.004

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Optimization of the Extraction Process of Flavonoids from Fructus Aurantii by Response Surface Method

LIU Xiao-hui1,WANG Yin-yue1,WANG Shi-ting1,ZHENG Xiao-qing1,TIAN Jia-ming1,WANG Jin1,ZHAO Yong-ming1,   

  1. 1 Department of Pharmacy,Hebei North University,Zhangjiakou,075000,China  2 Hebei Key Laboratory of Neuropharmacology,Zhangjiakou,075000,China
  • Online:2020-12-26 Published:2020-12-26
  • Contact: 赵永明,女,副教授,研究方向:主要从事天然产物活性成分开发;E-mail:519806096@qq.com
  • About author:刘晓慧,女,河北北方学院药学系学生
  • Supported by:
    河北省大学生创新创业训练计划(No.201810092013),河北北方学院项目(No.YB2018023),张家口市科技局项目(No.1411063C)

Abstract:

Objective:Box-Behnken experimental design was used to optimize the ultrasonic-assisted extraction process of the total flavonoids from Fructus Aurantii. Methods:Taking the extraction yield of total flavonoids from Fructus Aurantii as indexesthe single factor experiment and Box-Behnken experiment design were used to optimize the ethanol concentrationextraction time and material-to-liquid ratio. Results:The optimal condition established in this experiment was ethanol concentration of 14%ultrasonic extraction time of 27 minand material-to-liquid ratio of 144. Under these optimal conditionsthe extraction yield of the total flavonoids of Fructus Aurantii was 18.81 mg·g-1which was in line with the predicted value of the model. Conclusion: Ultrasound-assisted extraction of total flavonoids from Fructus Aurantii is feasible with less time and higher extraction yield. This study provide the foundation for further research on Fructus Aurantii.


Key words: Fructus Aurantii, flavonoids, the Box - Behnken design

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