ACTA NEUROPHARMACOLOGICA ›› 2020, Vol. 10 ›› Issue (6): 27-33.DOI: 10.3969/j.issn.2095-1396.2020.06.005

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Research Progress in Mechanism of Drug Resistance of Carbapenem-Resistant Klebsiella Pneumoniae

ZHAN Xu-li,TANG Jian-hua   

  1. Department of Pharmacy,the First Affiliated Hospital of Hebei North University,Zhangjiakou,075000,China
  • Online:2020-12-26 Published:2020-12-26
  • About author:詹旭莉,女,硕士研究生在读;研究方向:临床药学

Abstract:

Carbapenem-resistant Klebsiella pneumoniae(Carbapenem-resistant Klebsiella pneumoniaeCRKP)is one of the important pathogenic bacteria isolated clinically and nosocomial infections. As the beta lactam class and aminoglycoside the wide use of broad-spectrum antibioticsbacteria easy generation ultra broad spectrum beta lactamasecephalosporinsenzyme and aminoglycoside modifying enzymeto commonly used medicines including third-generation cephalosporin and aminoglycoside presents severe multiple drug resistance. Because CRKP is resistant to most antibioticsit has become a very difficult problem in clinical treatment. It has become important to strengthen the monitoring of bacterial resistance and reduce bacterial resistance caused by overuse of antibiotics. Thereforeit is necessary to systematically sort out CRKP and discuss its drug resistance mechanismso as to provide reference basis for rational selection of antibacterial drugs and optimization of medical resources in the future.


Key words: Carbapenem-resistant Klebsiella pneumoniae, carbapenemase-producing, outer membrane porin, efflux pump, biofilm

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