ACTA NEUROPHARMACOLOGICA ›› 2020, Vol. 10 ›› Issue (4): 29-35.DOI: 10.3969/j.issn.2095-1396.2020.04.006

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Bidirectional Adjusting Effects of Mesenchymal Stem Cells on Tumor Diseases

ZHAO Jiang-hao,CUI Shi-cong,GUO Chun-yan
  

  1. Hebei North University,Zhangjiakou,075000,China
  • Online:2020-08-26 Published:2020-08-26
  • Contact: 郭春燕,女,教授,博士,研究生导师;研究方向:天然药物活性成分和体内药物分析;E-mail:guochy0311@163.com
  • About author:赵江豪,男,2016 级药学本科生
  • Supported by:
    河北省教育厅重大项目(No.ZD2014075)

Abstract:

Mesenchymal stem cells (MSCs) are progenitors with strong proliferation and multi-differentiation potential. According to different sources,MSCs can be divided into bone marrow,placental,umbilical and fat mesenchymal stem cells. MSCs are promising candidates for cell-based therapies and for the promotion of tissue repair. However,the promotion effect of MSCs on tumor cells in some cases cannot be ignored. This paper reviews the recent literature on the bidirectional regulation of MSCs in tumor cells,and explores the mechanism and law of inhibiting or promoting the proliferation,migration and invasion of tumor cells,so as to provide reference for scientific and reasonable clinical trials of MSCs.

Key words: mesenchymal stem cells, tumor, dual-directional regulation, mesenchymal stem cell vector

CLC Number: