ACTA NEUROPHARMACOLOGICA ›› 2020, Vol. 10 ›› Issue (2): 19-23.DOI: 10.3969/j.issn.2095-1396.2020.02.005

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Study on the Content Determination Method of Flavone Dispersible Tablets of Herba Rabdosiae

LI Gang,ZHANG Ji,WANG Xin-Li,WANG Ya-nan,SHI Zong-yang   

  1. 1 College of Pharmacy,Hebei University,Baoding,071000,China
    2 Department of Pharmacy,Hebei North University,Zhangjiakou,075000,China
  • Online:2020-04-26 Published:2020-04-26
  • Contact: 张季,女,硕士,副教授;研究方向:中药药理学与药剂学研究;E-mail:zhangjizhji@126.com
  • About author:李港,男,硕士在读;研究方向:药物化学;E-mail:1210920834@qq.com

Abstract:

Objective:In order to determine the content of flavone in Herba Rabdosiae flavone dispersible tables simply and accurately. Methods:Building ultraviolet spectrophotometry method to the content of flavone in Herba Rabdosiae flavone dispersible tablets. Through chloride color development method and ultraviolet spectrophotometer with a detection wavelength of 410 nm to build standard substance of rutin of standard curve. Detect the content of flavone in Herba Rabdosiae flavone dsipersible tablets through the standard curve and the dissolution rate of Herba Rabdosiae flavone dsipersible tablets with little cup at 37℃. Results:The results showed that the linear relationship was good in the concentration range of 0.001~0.080 mg·mL-1,and the linear regression equation was Y=28.388X+0.017 6,R2=0.999 4. The dissolution rate of Herba Rabdosiae flavone dsipersible tablets dissolved 86.20% at the end. Almost all of them dissolved,and the dissolution rate was fast. Conclusion:Instruct the method of chloride color development to content of flavone in Herba Rabdosiae flavone dsipersible tablets is simply and accurately. The method have good veracity,high sensitivity and gong stability. Herba Rabdosiae flavone dsipersible tablets have good dissolution rate shows that they are good dsipersible tablets. And this method have many advantages like simple,accurate,quick and so on.

Key words: Herba Rabdosiae, dispersible tablets, flavone, UV, assaying