ACTA NEUROPHARMACOLOGICA ›› 2020, Vol. 10 ›› Issue (2): 1-.DOI: 10.3969/j.issn.2095-1396.2020.02.001

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Comparison of Analgesic Effects of Corydalis Yanhusuo,Radix Lindera,Jin Ling-zi powder and Xiao Huo-luo Dan on Rats with Neuropathic Pain#br#

JIAO Miao-miao,WANG Xu,ZHOU Na,ZHANG Meng,LIU Jin-na,TAN Zhan-wang,HUANG Dong-yang   

  1. College of Integrated Chinese and Western Medicine,Hebei Medical University,Shijiazhuang,050011,China
  • Online:2020-04-26 Published:2020-04-26
  • Contact: 黄东阳,博士,讲师;研究方向:分子药理学/ 神经药理学;Tel:+86-0311-86266445,E-mail:dongyang_huang@hotmail.com
  • About author:焦苗苗,本科;研究方向:方- 证相关研究;E-mail:jiaomiao1019@163.com
  • Supported by:
    2018 年大学生创新性实验计划项目(No.USIP2018003),河北省高等学校科学技术研究项目青年拔尖人才项目(No.BJ2017004),
    河北省自然科学基金优秀青年科学基金(No.C2018206222)

Abstract:

Objective:To compare the analgesic effects of Corydalis Yanhusuo,Radix Lindera,Jin Ling-zi powder and Xiao Huo-luo Dan on chronic neuropathic pain in rats with sciatic nerve chronic constriction injury (CCI). Methods:The male SD rats were randomly divided into 6 groups,sham operation group (n=13),saline group (n=13),Corydalis Yanhusuo group (n=16), Radix Lindera group (n=10),Jin Ling-zi powder group (n=20) and Xiao Huo-luo Dan group (n=7),respectively. Four days after the CCI surgery,the drugs were given by intragastric administration. The rats in Corydalis Yanhusuo group,Radix Lindera group,Jin Ling-zi powder group and Xiao Huo-luo Dan group were given 12 g·kg-1 drug respectively. The sham operation group and saline group were given the same amount of saline. The rats were administered intragastrically once a day for 14 consecutive days. From the beginning of the administration,the threshold of thermal pain was measured every other day by hot needling instrument. Results:Compared with Control group,the thermal threshold of Corydalis Yanhusuo group,Radix Lindera group,Jin Ling-zi powder group and Xiao Huo-luo Dan group were all increased,but the increase of Corydalis Yanhusuo group and Jin Ling-zi powder group were more significantly. Conclusion:Corydalis Yanhusuo,Radix Lindera,Jin Ling-zi powder and Xiao Huo-luo Dan all have analgesic effect on neuropathic pain,among which Jin Ling-zi powder has the strongest analgesic effect and the
fastest curative effect,followed by Corydalis Yanhusuo. The analgesic effects of Radix Lindera and Xiao Huo-luo Dan were not stable.

Key words: Corydalis Yanhusuo, Radix Lindera, Jin Ling-zi powder, Xiao Huo-luo Dan, neuropathic pain, analgesia