神经药理学报 ›› 2015, Vol. 5 ›› Issue (1): 38-44.

• 专题论著 • 上一篇    下一篇

胞外信号调控激酶(ERK)信号通路与抑郁症

李牧函,余冰颖,刘屏   

  1. 1.解放军总医院临床药理研究室,北京, 100853,中国
    2.北京中医药大学,北京,100029,中国
    3.河北北方学院,张家口,075000,中国
  • 出版日期:2015-02-26 发布日期:2015-07-06
  • 通讯作者: 刘屏,女,研究员,博士生导师,研究方向:神经药理与中药药理,Tel:+86-010-66936678,Email:liping301@126.com
  • 作者简介:李牧函,女,硕士,专业:中药药理学,Tel:+86-010-66936678,Email:limuhan0822@163.com
  • 基金资助:

    国家自然科学基金资助(No.81173430)

Extracellular Signal Regulated Kinase (ERK) Signaling Pathway and Depression

LI Mu-han, YU Bing-ying,  LIU Ping   

  1. 1. Department of Clinical Pharmacology, Chinese PLA General Hospital, Beijing, 100853, China
    2.  Beijing University of Chinese Medicine, Beijing, 100029, China
    3.  Hebei North University, Zhangjiakou, 075000, China
  • Online:2015-02-26 Published:2015-07-06
  • Contact: 刘屏,女,研究员,博士生导师,研究方向:神经药理与中药药理,Tel:+86-010-66936678,Email:liping301@126.com
  • About author:李牧函,女,硕士,专业:中药药理学,Tel:+86-010-66936678,Email:limuhan0822@163.com
  • Supported by:

    国家自然科学基金资助(No.81173430)

摘要: 胞外信号调控激酶(extracellular signal-regulated kinase,ERK)信号通路对神经细胞的生长、增殖、分化和存活起关键调节作用,并且对脑内突触可塑性和学习记忆有重要影响,因此ERK信号通路逐渐成为抗抑郁机制的研究热点。本文综述了近年来ERK信号通路在抑郁症发生和治疗方面的作用和机制,供同行参考。

关键词: 胞外信号调控激酶(ERK), 信号通路, 抑郁症

Abstract: The extracellular signal regulated kinase( ERK) signal pathway plays a key role in the growth,proliferation,differentiation and survival of neurons and has important effects on synaptic plasticity and learning and memory in the brain. Therefore,ERK signaling pathway has become a hot research topic in the research of anti-depression mechanism. This paper reviews the role and mechanism of ERK signaling pathway in the pathogenesis and treatment of depression in recent years.

Key words: extracellular signal regulated kinase (ERK), signaling pathway, depression

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