[1] Maurizio Popoli, Nicoletta Brunello, Jorge Perez, et al. Second messenger-regulated protein kinases in the brain: their functional role and the action of antidepressant drugs [J]. J Neurochem, 2000, 74(1): 21-33.[2] 怀特曼RM, 陈淳, 徐沁, 译. 高级分子生物学要义 [M]. 北京: 科学出版社, 2000.[3] Tal Almog, Zvi Naor. Mitogen activated protein kinases (MAPKs) as regulators of spermatogenesis and spermatozoa functions [J]. Molecular Cellular Endocrinology, 2008, 282(1-2):39-44 [4] Sabrina Davis, Peter Vanhoutte, Christiane Pages, et al. The MAPK/ERK cascade targets both Elk-1 and cAMP response element-binding protein to control long-term potentiation- dependent gene expression in the dentate gyrus in vivo [J]. J Neurosci, 2000, 20(12): 4563-4572.[5] Raphaela Fritsche-Guenther, Franziska Witzel, Anja Sieber, et al. Strong negative feedback from Erk to Raf confers robustness to MAPK signaling [J]. Mol Syst Biol, 2011, 7: 489.[6] Fritsche-Guenther R, Witzel F, Sieber A, et al. Strong negative feedback from Erk to Raf confers robustness to MAPK signaling [J]. Mol Syst Biol, 2011, 7: 489.[7] Dwivedi Y, Rizavi H S, Roberts R C, et al. Reduced activation and expression of ERK1/2 MAP kinase in the post-mortem brain of depressed suicide subjects [J]. J Neurochem, 2001, 77(3): 916-928. [8] Dwivedi Y, Rizavi H S, Conley R R, et al. ERK MAP kinase signaling in post-mortem brain of suicide subjects: differential regulation of upstream Raf kinases Raf-1 and B-Raf [J]. Mol Psychiatry, 2006, 11(1): 86-98. [9] Yuan Pei-xiong, Zhou Ru-lun, Wang Yun, et al. Altered levels of extracellular signal-regulated kinase signaling proteins in postmortem frontal cortex of individuals with mood disorders and schizophrenia [J]. J Affect Disord, 2010, 124(1-2): 164-169.[10] Catharine H Duman, Lee Schlesinger, Masafumi Kodama, et al. A role for MAP kinase signaling in behavioral models of depression and antidepressant treatment [J]. Biol Psychiatry, 2007, 61(5): 661-670.[11] Qi Xiao-li, Lin Wen-juan, Wang Dong-lin, et al. A role for the extracellular signal-regulated kinase signal pathway in depressive-like behavior [J]. Behav Brain Res, 2009, 199(2): 203-9.[12] 胡莺燕, 方贻儒, 禹顺英, 等. MEK基因多态性与抑郁症的关联性研究 [J]. 上海交通大学学报: 医学版, 2010, 30: 616-619.[13] Shi Cui-juan, Zhang Ke-rang, Xu Qi. Gender-specific role of the protein tyrosine phosphatase receptor type R gene in major depressive disorder [J]. J Affect Disord, 2012, 136(3): 591-598.[14] Adams J P, Sweatt J D. Molecular psychology: roles for the ERK MAP kinase cascade in memory [J]. Annu Rev Pharmacol Toxicol, 2002, 42: 135-163.[15] Thomas G M, Huganir R L. MAPK cascade signaling and synaptic plasticity [J]. Nat Rev Neurosci, 2004, 5(3): 173-183. [16] Wang Ling-xiao, Peng Dai-hui, Xie Bin, et al. The extracellular signal-regulated kinase pathway may play an important role in mediating antidepressant-stimulated hippocampus neurogenesis in depression [J]. Med Hypotheses, 2012, 79(1): 87-91.[17] Mogha A, Guariglia S R, Debata P R, et al. Serotonin 1A receptor-mediated signaling through ERK and PKCα is essential for normal synaptogenesis in neonatal mouse hippocampus [J]. Transl Psychiatry, 2012, 2: 1-12.[18] Pan Bin, Zhong Peng, Sun Da-long, et al. Extracellular signal-regulated kinase signaling in the ventral tegmental area mediates cocaine-induced synaptic plasticity and rewarding effects [J]. J Neurosci, 2011, 31(31): 11244-11255.[19] Jiang Wen, Zhang Yun, Xiao Lan, et al. Cannabinoids promote embryonic and adult hippocampus neurogenesis and produce anxiolytic- and antidepressant-like effects [J]. J Clin Invest, 2005, 115(11): 3104-3116.[20] Tian He-Ping, Huang Bao-Sheng, Zhao Jie, et al. Non-receptor tyrosine kinsae Src is required for ischemia-stimulated neuronal cell proliferation via Raf/ERK/CREB activation in the dentate gyrus [J]. BMC Neurosci, 2009, 10: 1-12.[21] Robert Waltereit, Michael Weller. Signaling from cAMP/PKA to MAPK and synaptic plasticity [J]. Mol Neurobiol, 2003, 27(1): 99-106.[22] Martina Gooney, Elhoucine Messaoudi, Frank Q Maher, et al. BDNF-induced LTP in dentate gyrus is impaired with age: analysis of changes in cell signaling events [J]. Neurobiol Aging, 2004, 25(10): 1323-1331.[23] Charlotte K Callaghan, Aine M Kelly. Differential BDNF signaling in dentate gyrus and perirhinal cortex during consolidation of recognition memory in the rat [J]. Hippocampus, 2012, 22(11): 2127-2135.[24] Zhang Han-ting, Zhao Yu, Huang Ying, et al. Inhibition of the phosphdiesterase 4 (PDE4) enzyme reverses memory deficits produced by infusion of the MEK inhibitor U0126 into the CA1 subregion of the rat hippocampus [J]. Neuropsychopharmacology, 2004, 29(8): 1432-1439.[25] Moosavi M, Khales G Y, Abbasi L, et al. Agmatine protects against scopolamine -induced water maze performance impairment and hippocampal ERK and Akt inactivation [J]. Neuropharmacology, 2012, 62(5-6): 2018-2023.[26] 胡晓旭. 盐酸羟哌吡酮(YL-0919)抗抑郁作用及其神经可塑性机制研究[D].泰安:泰山医学院, 2014.[27] Valeria Paola Carlini, Maria Belen Poretti, Mathias Rask-Andersen, et al. Differential effects of fluoxetine and venlafaxine on memory recognition: possible mechanisms of action [J]. Prog Neuropsychopharmacology Biol Psychiatry, 2012, 38(2): 159-167.[28] Huang E J, Reichardt L F. Trk receptors: roles in neuronal signal transduction [J]. Annu Rev Biochem, 2003, 72: 609-642. [29] Maharana C, Sharma K P, Sharma S K. Feedback mechanism in depolarization -induced sustained activation of extracellular signal-regulated kinase in the hippocampus [J]. Sci Rep, 2013, 3: 1-6.[30] 蒋先仲, 李云峰, 张有志, 等. 抑郁症与脑内CREB的调节 [J]. 解放军药学学报, 2007, 23(2): 127-129.[31] Kumamaru E, Numakawa T, Adachi N, et al. Glucocorticoid suppresses BDNF -stimulated MAPK/ERK pathway via inhibiting interaction of Shp2 with TrkB [J]. FEBS Lett, 2011, 585(20): 3324-3328.[32] Rachael W Sirianni, Peter Olausson, Amy S Chiu, et al. The behavioral and biochemical effects of BDNF containing polymers implanted in the hippocampus of rats [J]. Brain Res, 2010, 1321: 40-50.[33] Heath D Schmidt, Ronald S Duman. Peripheral BDNF produces antidepressant-like effects in cellular and behavioral models [J]. Neuropsychopharmacology, 2010, 35(12): 2378-2391.[34] 汪婷婷,董宪喆,刘婉婉,等. 人参皂苷Rb_1,Rg_1和Re调控Raf-CREB,Akt-CREB,CaMKⅡ-CREB信号转导通路的体外研究[J]. 中国中药杂志,2014,11:2065-2070.[35] 吴海芬,朱春晖,郭建友. 人参皂苷Rg1对抑郁症模型大鼠行为学及海马氨基酸的影响[J]. 中国中药杂志,2012,37(20) : 3117.[36] 古文娟,刘頔,张孟仁,张宏. 人参皂苷Rb1对高糖培养海马神经元胰岛素信号转导途径的影响[J]. 中国中药杂志,2014, 39(6): 1064.[37] Liu P, Hu Y, Guo DH, et al. Potential antidepressant properties of Radix Polygalae (Yuan Zhi)[J]. Phytomedicine, 2010 Aug; 17(10):794-799. [38] Hu Yuan, Liu Ming-yue, Liu Ping, et al. Neuroprotective effects of 3,6'-disinapoyl sucrose through increased BDNF levels and CREB phosphorylation via the CaMKII and ERK1/2 pathway[J]. J Mol Neurosci, 2014, 53(4):600-607.[39] Dong Xian-zhe, Huang Cui-li, Yu Bing-ying, et al. Effect of Tenuifoliside A isolated from Polygala tenuifolia on the ERK and PI3K pathways in C6 glioma cells[J]. Phytomedicine, 2014, 21(10):1178-88.[40] First M, Gil-Ad I, Taler M, et al. The effects of reboxetine treatment on depression -like behavior, brain neurotrophins, and ERK expression in rats exposed to chronic mild stress [J]. J Mol Neurosci, 2012, 50(1):88-97. [41] Maha M Elbatsh, M A A Moklas, C A Marsden, et al. Antidepressant-like effects of Δ9-tetrahydrocannabinol and rimonabant in the olfactory bulbectomised rat model of depression [J]. Pharmacol Biochem Behav, 2012, 102(2): 357-365.[42] Zhang Lin, Xu Tian-yuan, Wang Shuang, et al. Curcumin produces antidepressant effects via activating MAPK/ERK-dependent brain-derived neurotrophic factor expression in the amygdala of mice [J]. Behav Brain Res, 2012, 235(1): 67-72.[43] Magariños A M, McEwen B S. Stress-induced atrophy of apical dendrites of hippocampal CA3c neurons: comparison of stressors[J]. Neuroscience, 1995, 69(1): 83-88. [44] Ryo Hashimoto, Yu Jing, Hideki Koizumi, et al. Ginsenoside Rb1 prevents MPP+-induced apoptosis in PC12 cells by stimulating estrogen receptors with consequent activation of ERK1/2, Akt and inhibition of SAPK/JNK, p38MAPK [J]. Evid Based Complement Alternat Med, 2012, 2012:693717.[45] Lukasz R Drzyzga, Agnieszka Marcinowska, Ewa Obuchowicz. Antiapoptotic and neurotrophic effects of antidepressants: a review of clinical and experimental studies [J]. Brain Res Bull, 2009, 79(5): 248-257. |