| Zhang Jin-ying，Deng Zi-hui，Liao Jie，et al. Leptin attenuates cerebral ischemia injury through the promotion of energy metabolism via the PI3K/Akt pathway[J]. J Cereb Blood Flow Metab, 2013, 33(4): 567-574.[2] Liu Zhen-quan, Li Peng-tao, Zhao Dan, et al. Protective effect of extract of Cordyceps sinensis in middle cerebral artery occlusion-induced focal cerebral ischemia in rats[J]. Behav Brain Funct, 2010, 6: 61-67.[3] Ornella Cuomo, Rosaria Gala, Giuseppe Pignataro, et al. A critical role for the potassium-dependent sodium-calcium exchanger NCKX2 in protection against focal ischemic brain damage[J]. J Neurosci, 2008, 28(9): 2053-2063.[4] Qin Ai-ping, Zhang Hui-ling, Qin Zheng-hong. Mechanisms of lysosomal proteases participating in cerebral ischemia-induced neuronal death[J]. Neurosci Bull, 2008, 24(2): 117-123.[5] 韩征宇, 李光来. 左卡尼汀对局灶性脑缺血再灌注损伤大鼠ATP酶活性的影响[J]. 中西医结合心脑血管病杂志, 2010, 8(01): 77-78.[6] Edith Lubos, Diane E Handy, Joseph Loscalzo. Role of oxidative stress and nitric oxide in atherothrombosis[J]. Front Biosci, 2008, 135323-135344.[7] Ayman Elali, Thorsten R Doeppner, Anil Zechariah, et al. Increased blood-brain barrier permeability and brain edema after focal cerebral ischemia induced by hyperlipidemia: role of lipid peroxidation and calpain-1/2, matrix metalloproteinase-2/9, and RhoA overactivation[J]. Stroke, 2011, 42(11): 3238-3244.[8] Marta Di Carlo, Danniela Giacomazza, Pasquale Picone, et al. Are oxidative stress and mitochondrial dysfunction the key players in the neurodegenerative diseases?[J]. Free Radic Res, 2012, 46(11): 1327-1338.[9] Papi A, Contoli M, Gasparini P, et al. Role of xanthine oxidase activation and reduced glutathione depletion in rhinovirus induction of inflammation in respiratory epithelial cells[J]. J Biol Chem, 2008, 283(42): 28595-28606.[10] Danielle M Friend, Jong H Son, Kristen A Keefe, et al. Expression and activity of nitric oxide synthase isoforms in methamphetamine-induced striatal dopamine toxicity[J]. J Pharmacol Exp Ther, 2013, 344(2): 511-521.[11] Abhilasha Ahlawat, Ajay Rana, Nidhi Goyal, et al. Potential role of nitric oxide synthase isoforms in pathophysiology of neuropathic pain[J]. Inflammopharmacology, 2014, 22(5): 269-278.[12] 韩征宇, 李光来. 左卡尼汀对脑缺血再灌注损伤的抗氧化作用及其机制研究[J]. 临床医药实践, 2010, 19(01): 18-20.[13] 陈达. 左卡尼汀对心肺复苏术后大鼠脑神经细胞氧自由基损伤的保护作用[J]. 医学临床研究, 2011, 11(28): 2036-40.[14] Wainwright M S, Kohli R, Whitington P F, et al. Carnitine treatment inhibits increases in cerebral carnitine esters and glutamate detected by mass spectrometry after hypoxia-ischemia in newborn rats[J]. Stroke, 2006, 37(2): 524-530.[15] 刘彦儒. 左卡尼汀对急性脑梗死患者临床疗效的观察[D]. 2011, 太原：山西医科大学.[16] Li Jin-lian, Wang Qiao-yun, Luan Hai-yun, et al. Effects of L-carnitine against oxidative stress in human hepatocytes: involvement of peroxisome proliferator-activated receptor alpha[J]. J Biomed Sci, 2012, 19: 32-41.[17] Helen Konnecke, Ingo Bechmann. The role of microglia and matrix metalloproteinases involvement in neuroinflammation and gliomas[J]. Clin Dev Immunol, 2013, 2013: 914104.[18] Soonmi Won, Jin Hwan Lee, Bushra Wali, et al. Progesterone attenuates hemorrhagic transformation after delayed tPA treatment in an experimental model of stroke in rats: involvement of the VEGF-MMP pathway[J]. J Cereb Blood Flow Metab, 2014, 34(1): 72-80.[19] Tyler Duellman, Christopher Warren, Jay Yang. Single nucleotide polymorphism-specific regulation of matrix metalloproteinase-9 by multiple miRNAs targeting the coding exon[J]. Nucleic Acids Res, 2014, 42(9): 5518-5531.[20] Ji Hae Seo, Nobukazu Miyamoto, Kazuhide Hayakawa, et al. Oligodendrocyte precursors induce early blood-brain barrier opening after white matter injury[J]. J Clin Invest, 2013, 123(2): 782-786.[21] Sophie Gautier, Thavarak Ouk, Madjid Tagzirt, et al. Impact of the neutrophil response to granulocyte colony-stimulating factor on the risk of hemorrhage when used in combination with tissue plasminogen activator during the acute phase of experimental stroke[J]. J Neuroinflammation, 2014, 11: 96-106.[22] Minoru Asahi, Kazuko Asahi, Jae-Chang Jung, et al. Role for matrix metalloproteinase 9 after focal cerebral ischemia: effects of gene knockout and enzyme inhibition with BB-94[J]. J Cereb Blood Flow Metab, 2000, 20(12): 1681-6819.[23]. Zhang Xiao-jun, Wang Yang, Yamamoto Gou, et al. Expression of matrix metalloproteinases MMP-2, MMP-9 and their tissue inhibitors TIMP-1 and TIMP-2 in the epithelium and stroma of salivary gland pleomorphic adenomas[J]. Histopathology, 2009, 55(3): 250-260.[24] 杨陆. 乳清酸左卡尼汀对大鼠脑缺血再灌注后血脑屏障的保护作用[J]. 辽宁医学院学报, 2011, 01(32): 1-5.[25] 蔡鸿, 易韦, 李玫, 等. 左-卡尼汀对急性脑梗死患者血浆基质金属蛋白酶的影响[J]. 现代预防医学, 2010, 37(12): 2353-2354+2356.[26]. Wang S, Wei H, Cai M, et al. Genistein attenuates brain damage induced by transient cerebral ischemia through up-regulation of ERK activity in ovariectomized mice[J]. Int J Biol Sci, 2014, 10(4): 457-465.[27] Mahmoud Mahmoudi, Shahrzad Zamani Taghizadeh Rabe, Mahdi Balali-Mood, et al. Ursolic acid induced apoptotic cell death following activation of caspases in isolated human melanoma cells[J]. Cell Biol Int, 2015, 39(2): 230-236.[28]. Ivana Pilchova, Katarina Klacanova, Maria Chomova, et al. Possible contribution of proteins of Bcl-2 family in neuronal death following transient global brain ischemia[J]. Cell Mol Neurobiol, 2015, 35(1): 23-31.[29] Lavanya Yaidikar, Santhrani Thakur. Punicalagin attenuated cerebral ischemia-reperfusion insult via inhibition of proinflammatory cytokines, up-regulation of Bcl-2, down-regulation of Bax, and caspase-3[J]. Mol Cell Biochem, 2015, 402(1-2): 141-148.[30] Zhou Yun-chuan, Zhou Yang, Yu shan-shan, et al. Sulfiredoxin-1 exerts anti-apoptotic and neuroprotective effects against oxidative stress-induced injury in rat cortical astrocytes following exposure to oxygen-glucose deprivation and hydrogen peroxide[J]. Int J Mol Med, 2015, 36(1): 43-52.[31] Wang Xuan, Jiang Cui-min, Wan Hai-ying, et al. Neuroprotection against permanent focal cerebral ischemia by ginkgolides A and B is associated with obstruction of the mitochondrial apoptotic pathway via inhibition of c-Jun N-terminal kinase in rats[J]. J Neurosci Res, 2014, 92(2): 232-242.[32] Mia Kim, Mai Soon Shin, Jae Min Lee, et al. Inhibitory Effects of Isoquinoline Alkaloid Berberine on Ischemia-Induced Apoptosis via Activation of Phosphoinositide 3-Kinase/Protein Kinase B Signaling Pathway[J]. Int Neurourol J, 2014, 18(3): 115-125.[33] Tao Tao, Liu Yan, Zhang Jing-yue, et al. Therapeutic hypercapnia improves functional recovery and attenuates injury via antiapoptotic mechanisms in a rat focal cerebral ischemia/reperfusion model[J]. Brain Res, 2013, 153352-153362.[34] Saad M A, Abdelsalam R M, Kenawy S A, et al. Montelukast, a cysteinyl leukotriene receptor-1 antagonist protects against hippocampal injury induced by transient global cerebral ischemia and reperfusion in rats[J]. Neurochem Res, 2015, 40(1): 139-150.[35] Calvani M, Reda E, Arrigoni-Martelli E. Regulation by carnitine of myocardial fatty acid and carbohydrate metabolism under normal and pathological conditions[J]. Basic Res Cardiol, 2000, 95(2): 75-83.[36] Picconi B, Barone I, Pisani A, et al. Acetyl-L-carnitine protects striatal neurons against in vitro ischemia: the role of endogenous acetylcholine[J]. Neuropharmaology, 2006, 50(8): 917-923.[37] 韩征宇. 左卡尼汀对大鼠脑缺血再灌注损伤的保护作用及机制[D]. 2010, 太原：山西医科大学.[38] 张雷, 王建华, 刘瑞珍. 左卡尼汀对大鼠脑缺血再灌注损伤后Bcl-2和血管内皮生长因子表达的影响[J]. 山西医药杂志, 2010, 39(12): 1115-1117.[39] 王慧敏. 左卡尼汀对复苏后多脏器功能障碍大鼠脑保护作用的实验研究[D]. 2012, 太原：山西医科大学.[40] 段琼玉. 左卡尼汀对大鼠急性放射性脑损伤后脑组织Caspase-3和Bcl-2表达的影响[D]. 2012, 沈阳：中国医科大学.[41] 张雷, 林兆奋, 缪明永, 等. 心肺复苏后大鼠脑细胞线粒体呼吸功能的变化及左卡尼汀的干预作用[J]. 药学服务与研究, 2005, 5(03): 259- 262.[42] Liu Qi, Kurt Fredrick. Contribution of intersubunit bridges to the energy barrier of ribosomal translocation[J]. Nucleic Acids Res, 2013, 41(1): 565-74.[43] Virmani M A, Caso V, Spadoni A, et al. The action of acetyl-L-carnitine on the neurotoxicity evoked by amyloid fragments and peroxide on primary rat cortical neurones[J]. Ann N Y Acad Sci, 2001: 939162- 939178 |
