小胶质细对炎症介导的帕金森氏病的影响

神经药理学报 ›› 2012, Vol. 2 ›› Issue (4): 28-31.

小胶质细对炎症介导的帕金森氏病的影响

^{魏巍^1,2 ，苑玉和¹ ，陈乃宏¹}

1. 天然药物活性物质与功能国家重点实验室，新药作用机制研究与药效评价北京市重点实验室,中国医学科学院药物研究所，北京，100050，中国
2. 天津中医药大学，天津，300193，中国

出版日期:2012-08-26 发布日期:2014-06-27
通讯作者: 陈乃宏，男，教授；研究方向：神经药理学；Tel: +86-010-63165177，Fax: +86-010-63165177，E-mail: chennh@imm.ac.cn
作者简介:魏巍，女，硕士研究生；研究方向：神经药理学；E-mail：1375913971@qq.com
基金资助:
国家863计划基金（No.2012AA020303），长江学者和创新团队发展计划(PCSIRT No.IRT1007)，国家自然科学基金（No.81274122、No.81173578），国家国际科技合作项目(No.2010DFB32900)，创新药物研究开发技术平台建设（No.2012ZX09301002-004、No.2012ZX09103101-006），教育部博士点基金重点项目(No.20121106130001)，北京市自然基金重点项目(No.7131013)

The Effect of Microglial Cells on Parkinson’s Diseases

^{WEI Wei^1,2 YUAN Yu-he¹ CHEN Nai-hong¹}

1. State Key Laboratory of Bioactive Substances and Functions of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100050, China
2. Tianjin University of Traditional Chinese Medicine, Tianjin, 300193, China

Online:2012-08-26 Published:2014-06-27
Contact: 陈乃宏，男，教授；研究方向：神经药理学；Tel: +86-010-63165177，Fax: +86-010-63165177，E-mail: chennh@imm.ac.cn
About author:魏巍，女，硕士研究生；研究方向：神经药理学；E-mail：1375913971@qq.com
Supported by:
国家863计划基金（No.2012AA020303），长江学者和创新团队发展计划(PCSIRT No.IRT1007)，国家自然科学基金（No.81274122、No.81173578），国家国际科技合作项目(No.2010DFB32900)，创新药物研究开发技术平台建设（No.2012ZX09301002-004、No.2012ZX09103101-006），教育部博士点基金重点项目(No.20121106130001)，北京市自然基金重点项目(No.7131013)

摘要/Abstract

摘要： 大量事实表明小胶质细胞在退行性神经系统疾病，包括阿尔茨海默氏病和帕金森氏病的神经退化过程中都有很大的影响。而关于小胶质细胞在神经退行性疾病中究竟起着什么样的作用仍有待确定，但当小胶质细胞过度激活最后都会导致神经元的死亡。激活的小胶质细胞会分泌多种诱发或加重神经退行性疾病的炎症因子或神经毒素。系统性炎症是慢性神经退行性疾病患者相关功能下降的主要诱因之一。本文，对小胶质细胞在神经退行性疾病的发病机制中所产生的作用，特别是小胶质细胞对于帕金森氏病的动物和细胞培养模型的研究进展，及新的方法和潜在的治疗策略进行综述。

关键词: 帕金森病, 神经炎症, 小胶质细胞

Abstract: Microglial cells play an essential role in degenerative neurological diseases, including neurodegenerative process of Alzheimer's disease and Parkinson's disease. However, it is yet unclear the exact roles of microglia cells in neurodegenerative diseases plays, although it is known that excessive activation of microglia will ultimately lead to neuronal death. Activated microglia secrete a variety of inflammatory and neurotoxic factors that may aggrevate neurodegenerative diseases. In fact, systemic inflammation is one of the main causes attributable to chronic neurodegenerative diseases related functions decline. In this article, we summarized the role of microglial cells in the pathogenesis of neurodegenerative diseases. In addition, we also discussed new methods and potential therapeutic strategies of neurodegenerative disorders.

Key words: Parkinson's disease, neuroinflammation, microglia

中图分类号:

R965

魏巍，苑玉和，陈乃宏. 小胶质细对炎症介导的帕金森氏病的影响[J]. 神经药理学报, 2012, 2(4): 28-31.

WEI Wei， YUAN Yu-he， CHEN Nai-hong. The Effect of Microglial Cells on Parkinson’s Diseases[J]. Acta Neuropharmacologica, 2012, 2(4): 28-31.

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