Toll样受体信号转导与中枢神经系统疾病

神经药理学报 ›› 2012, Vol. 2 ›› Issue (4): 32-39.

Toll样受体信号转导与中枢神经系统疾病

武海霞，吴志刚，刘红彬，沈丽霞

河北北方学院药学系，张家口，075000，中国

出版日期:2012-08-26 发布日期:2014-06-27
通讯作者: 沈丽霞，女，博士，教授；研究方向：神经药理学；Tel：+86-0313-4029423，E-mail：shenlixiacn@163.com
作者简介:武海霞，女，硕士，讲师；研究方向：神经药理学；Tel：+86-0313-4029305，E-mail：wuhaixia_zjk@126.com
基金资助:
河北省自然科学基金资助项目（No.H2012405016），河北省教育厅资助项目（No.Z2013069），河北北方学院创新人才培育基金（CXRC1325），2013年度河北北方学院校级重大项目（ZD201310）

Signal Transduction of Toll-like Receptors and the Central Nervous System Disease

WU Hai-xia,WU Zhi-gang,LIU Hong-bin,SHEN Li-xia

Department of Pharmacy, Hebei North University, Zhangjiakou, 075000, China

Online:2012-08-26 Published:2014-06-27
Contact: 沈丽霞，女，博士，教授；研究方向：神经药理学；Tel：+86-0313-4029423，E-mail：shenlixiacn@163.com
About author:武海霞，女，硕士，讲师；研究方向：神经药理学；Tel：+86-0313-4029305，E-mail：wuhaixia_zjk@126.com
Supported by:
河北省自然科学基金资助项目（No.H2012405016），河北省教育厅资助项目（No.Z2013069），河北北方学院创新人才培育基金（CXRC1325），2013年度河北北方学院校级重大项目（ZD201310）

摘要/Abstract

摘要： Toll样受体（toll-like receptors，TLRs）是一类模式识别受体，在药物研究领域受到广泛关注。TLRs能特异地识别病原相关的分子模式，在激活天然免疫和调节获得性免疫中发挥重要作用。近年来，TLRs信号转导在中枢神经系统疾病方面的研究进展迅速。本文对TLRs信号传递新进展及TLRs在中枢神经系统疾病中的研究现状进行综述

关键词: Toll样受体, 信号转导, 中枢神经系统疾病

Abstract: Toll-like receptors (TLRs) are pattern recognition receptors(PRRs) and attracted attention in the field of drug research broadly. TLRs can specific to identify the pathogen associated molecular patterns(PAMPs) and play an important role in the process of activation of innate immune and regulating acquired immune. In recent years, studies on TLRs signal transduction associated with the central nervous system diseases progress quickly. The research status about new progresses of TLRs signaling and their roles in the central nervous system diseases were reviewed.

Key words: Toll-like receptors, signal transduction, central , nervous , system , disease

中图分类号:

R965

武海霞，吴志刚，刘红彬，沈丽霞. Toll样受体信号转导与中枢神经系统疾病[J]. 神经药理学报, 2012, 2(4): 32-39.

WU Hai-xia,WU Zhi-gang,LIU Hong-bin,SHEN Li-xia. Signal Transduction of Toll-like Receptors and the Central Nervous System Disease[J]. Acta Neuropharmacologica, 2012, 2(4): 32-39.

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