神经药理学报

神经药理学报 ›› 2024, Vol. 14 ›› Issue (6): 36-.DOI: 10.3969/j.issn.2095-1396.2024.06.005

• 研究论文 • 上一篇    下一篇

盐酸美金刚治疗帕金森痴呆临床疗效分析

刘昌佳，闫昆   

  1. 河北北方学院附属第二医院神经内科，张家口，075100，中国
  • 出版日期:2024-12-26 发布日期:2024-12-26
  • 作者简介:刘昌佳，副主任医师；研究方向：神经系统疾病
  • 基金资助:
    张家口市科学技术科研重点项目（No.2121176D）

Analysis of Clinical Efficacy of Memantine Hydrochloride in the Treatment of Parkinson's Dementia Patients

LIU Chang-jia, YAN Kun   

  1. Department of Neurology, The Second Affiliated Hospital of Hebei North University, Zhangjiakou, 075100, China
  • Online:2024-12-26 Published:2024-12-26

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摘要：

目的：探讨盐酸美金刚辅助治疗帕金森痴呆应用效果。方法：河北北方学院附属第二医院神经内科收治 的60 例帕金森痴呆患者随机分为对照组（盐酸多奈哌齐组）与观察组（盐酸美金刚组）各30 例，观察临床治疗效果。 结果：观察组治疗总有效率显著高于对照组（P<0.05），简易智力状态检查量表（mini-mental state examination, MMSE）评分高于对照组（P<0.01），不良反应发生率组间差异无统计学意义（P>0.05）。结论：盐酸美金刚辅助治 疗帕金森痴呆临床效果显著，有助于患者尽快恢复日常生活能力与认知功能，安全性较高，值得临床推广使用。

关键词: 盐酸美金刚, 盐酸多奈哌齐, 帕金森, 痴呆

Abstract:

Objective: To explore the application effect of memantine hydrochloride in the adjuvant treatment of Parkinson 's dementia. Methods: 60 patients with Parkinson 's dementia were randomly divided into control group (donepezil hydrochloride group) and observation group (memantine hydrochloride group), 30 cases in each group. Results: The total effective rate of the observation group was significantly higher than that of the control group (P<0.05), and the MMSE scale score was higher than that of the control group (P<0.05). There was no significant difference in the incidence of adverse reactions between the two groups (P>0.05). Conclusion: The clinical effect of memantine hydrochloride in the adjuvant treatment of Parkinson's dementia is significant, which is helpful for patients to restore their daily living ability and cognitive function as soon as possible. It is safe and worthy of clinical application.

Key words: memantine hydrochloride, donepezil hydrochloride, Parkinson, dementia

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