神经药理学报 ›› 2017, Vol. 7 ›› Issue (3): 12-20.DOI: 10.3969/j.issn.2095-1396.2017.03.003
任倩，王真真，陈乃宏
出版日期:2017-06-26
发布日期:2017-12-01
通讯作者:
陈乃宏，男，博士，研究员；研究方向：神经药理及神经分子生物学；Tel：+86-10-63165177，Fax：86-10-63165211，E-mail：chennh@imm.ac.cn
作者简介:任倩，女，硕士，研究生；研究方向：神经药理及神经分子生物学；Tel：+86-10-63165211，E-mail：renqian@imm.ac.cn
基金资助:国家自然科学基金项目（No.81573636，U1402221，81560663），北京协和医学院“协和青年基金”（ No.3332016058），中央级公益性科研院所基本科研业务费专项资金（No.2014RC03，2016RC350002），湖南省重点研发计划项目（No.2015SK2029-1），湖南省教育厅高校科研经费开放基金项目（No.15K091），新药作用机制研究与药效评价北京市重点实验室资助项目（No.BZ0150）
REN Qian 1，WANG Zhen-zhen 1，CHEN Nai-hong 1，2
Online:2017-06-26
Published:2017-12-01
Contact:
陈乃宏，男，博士，研究员；研究方向：神经药理及神经分子生物学；Tel：+86-10-63165177，Fax：86-10-63165211，E-mail：chennh@imm.ac.cn
About author:任倩，女，硕士，研究生；研究方向：神经药理及神经分子生物学；Tel：+86-10-63165211，E-mail：renqian@imm.ac.cn
Supported by:国家自然科学基金项目（No.81573636，U1402221，81560663），北京协和医学院“协和青年基金”（ No.3332016058），中央级公益性科研院所基本科研业务费专项资金（No.2014RC03，2016RC350002），湖南省重点研发计划项目（No.2015SK2029-1），湖南省教育厅高校科研经费开放基金项目（No.15K091），新药作用机制研究与药效评价北京市重点实验室资助项目（No.BZ0150）
摘要： 抑郁症是一种危害人类身心健康的慢性、易复发的常见精神心理疾病，有很高的致死致残率。MicroRNA（miRNA）是一类近年发现的在生物体内广泛分布的长约 22 个核苷酸的新型微小非编码 RNA。它通常是通过与靶 mRNA 的 3’UTR 结合，抑制 mRNA 翻译或调节 mRNA 降解来调控生物体内一系列的生理、病理过程。近年来研究表明抑郁症患者神经元结构和功能，神经元突触传递与可塑性等发生改变，基因表达增加，而 miRNA 发挥重要的调控作用。该文就近年来miRNA 在抑郁症中调控神经可塑性的研究进展进行综述，以期为深入认识和治疗抑郁症带来新的启示。
中图分类号:
任倩，王真真，陈乃宏. MicroRNA调控神经可塑性在抑郁症中作用研究进展[J]. 神经药理学报, 2017, 7(3): 12-20.
REN Qian,WANG Zhen-zhen,CHEN Nai-hong. Regulation of Neuroplasticity by MicroRNA in Depression Disorder[J]. Acta Neuropharmacologica, 2017, 7(3): 12-20.
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