帕金森病致病基因Parkin的研究进展

摘要/Abstract

摘要： 帕金森病在全球神经退行性疾病中的发病率中，仅次于阿尔茨海默症。Parkin是帕金森病的相关致病基因之一，自日本学者发现证实其与帕金森病发病相关以来，关于Parkin的研究迅速发展。Parkin的基本结构和生理功能、蛋白底物、相关基因以及其致病机制已被众多文献报道，本文综述了Parkin及蛋白的结构，并对Parkin的泛素-蛋白体酶系统详细介绍，指出了Parkin的相关反应物以及和线粒体的关系，并对其发展前景提出设想。

关键词: Parkin, 帕金森病, 底物, 基因突变, 泛素化

Abstract: In the global neurodegenerative diseases，the incidence of Parkinson is second only to Alzheimer’s disease. Parkin is one of the gene which associated with Parkinson’s disease. Since the hypothesis that Parkin is associated with the Parkinson’s disease was confirmed by Japannese scholar，the researches about it were developed rapidly. The basic structure，physiological function，the protein substrates and related genes，accompanied their pathogenic mechanisms of Parkin have been reported in numerous literature. This paper describes the structure and protein of Parkin，reviews Parkin and its ubiquitin-protein enzyme system in detail，describes the relationship between Parkin and that the relevant reactants and mitochondria，and proposes ideas for their development prospects.

Key words: Parkin, Parkinson&, rsquo, s disease, Substrates, Gene mutation, Ubiquitination

中图分类号:

R964

姜懿纳, 陈乃宏. 帕金森病致病基因Parkin的研究进展[J]. 神经药理学报, 2015, 5(3): 36-45.

JIANG Yi-na, CHEN Nai-hong. Advances in Parkinson’s Disease-Causing Gene Parkin[J]. ACTA NEUROPHARMACOLOGICA, 2015, 5(3): 36-45.

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