黄酮类化合物防治阿尔兹海默病及药物研发研究进展

摘要/Abstract

摘要： 黄酮类化合物是一类存在于多种植物中、数量种类繁多、结构复杂多样的次生代谢产物，也是多种中草药的活性成分。大量基础研究表明黄酮类化合物在多种疾病的发生发展中发挥了积极的作用，在抗阿尔茨海默病（Alzheimer’s Disease， AD）的基础与动物模型研究中，发现黄酮类化合物能够有效改善AD模型动物的学习记忆能力，延迟疾病病理进程，通过减少炎性介质产生、抑制 Aβ聚集和tau蛋白磷酸化、阻断自由基产生等多条途径调节细胞信号通路，缓解氧化应激状态，最终起到神经保护作用。本文综述了黄酮类化合物在AD中的药理作用及可能的作用机制，为黄酮类化合物抗AD的药物研发提供一些启示。

关键词: 阿尔兹海默病, 黄酮类化合物, 神经炎症, A&, beta, 氧化应激

Abstract: Flavonoids, a class of secondary metabolites present in plants, are the active ingredients of a variety of herbals. An increasing body of evidences demonstrate that the flavonoids could significantly improve the cognitive function of Alzheimer’s diseases (AD) in animal models and alleviate the progression of AD, exerting positive therapeutic effect. The mechanism is complex, including suppressing inflammatory modulators production, inhibiting Aβ aggregation and tau protein phosphorylation, and reducing the generation of free radical generation through multiple intracellular signaling pathways. Summarizing the relationship between the structure and their biological actions of the flavonoids and the possible mechanisms in the treatment of AD, the aim of this review, is to obtain a further understanding of how flavonoids participate in relieving the progression of AD and providing some inspiration for the flavonoids applying in AD treatment.

Key words: Alzheimer&, rsquo, s disease, flavonoids compound, neuroinflammation, A&, beta, oxidative stress

中图分类号:

R964

周思百，李金泽，刘睿，张天泰. 黄酮类化合物防治阿尔兹海默病及药物研发研究进展[J]. 神经药理学报, 2015, 5(1): 51-58.

ZHOU Si-bai, LI Jin-ze, LIU Rui, ZHANG Tian-tai. Recent Development of the Flavonoids on the Treatment of Alzheimer’s Disease[J]. Acta Neuropharmacologica, 2015, 5(1): 51-58.

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