灯盏花素神经保护作用及其机制研究进展

摘要/Abstract

摘要： 灯盏花素是中药灯盏细辛主要的有效单体之一，属于黄酮类活性成分。研究表明，灯盏花素在脑损伤中具有很好的神经保护作用，其机制可能包括：改善能量代谢，清除自由基，抑制细胞内Ca2+超载、兴奋性氨基酸毒性、炎症反应，调节脑内血管活性物质的产生，抑制神经元凋亡等。灯盏花素具有良好的临床应用前景，该文对灯盏花素近年来神经保护作用研究进展作一综述。

关键词: 灯盏花素, 氧化应激, Ca2+超载, 炎症介质, 细胞凋亡

Abstract: Breviscapine is an active component of the herbal medicine (Radix et Herba Erigeri Breviscapi). It has been proved that breviscapine has neuroprotective effects on injured brain in many studies. Its mechanisms are involved in improving energy metabolism, scavenging free radical, restraining Ca2+ overload, excitatory amino acid virulence, and inflammatory response, regulating the produce of vasoactive substance and inhibiting neuronal apoptosis. It is a potential compound with a broad clinical application. This paper mainly discussed the protective effects and mechanisms of breviscapine on the nervous system.

Key words: breviscapine, oxidative stress, Ca2+ overload, inflammatory mediator, apoptosis

中图分类号:

R964

颜娟, 郑茂东. 灯盏花素神经保护作用及其机制研究进展[J]. 神经药理学报, 2014, 4(3): 31-38.

YAN Juan，ZHENG Mao-Dong. Protective Effects and Mechanisms of Breviscapine on the Nervous System[J]. Acta Neuropharmacologica, 2014, 4(3): 31-38.

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