亨廷顿舞蹈症、氧化应激与胶质细胞

神经药理学报 ›› 2014, Vol. 4 ›› Issue (3): 22-30.

亨廷顿舞蹈症、氧化应激与胶质细胞

高岩, 楚世峰, 陈乃宏

天然药物活性物质与功能国家重点实验室，新药作用机制研究与药效评价北京市重点实验室，中国医学科学院北京协和医学院药物研究所 & 神经科学中心，北京，100050，中国

出版日期:2014-06-26 发布日期:2015-01-20
通讯作者: 陈乃宏，男，研究员，博士生导师；研究方向：神经精神药理学；Tex/Fax：010-63165182，010-63165177，E-mail：chennh@imm.ac.cn
作者简介:高岩，女，博士研究生；研究方向：神经精神药理学；E-mail：gaoyan@imm.ac.cn
基金资助:
国家自然科学基金项目（Nos. 81274122、81102831、81173578、81202507、81273629、81373510），国家“重大新药创制”科技重大专项（Nos. 2012ZX09301002-004、2012ZX09103101-006），国家高技术研究发展计划（863 计划）（No. 2012AA020303），教育部长江学者和创新团队发展计划（PCSIRT）（No. IRT1007），教育部博士点基金重点项目（No. 20121106130001），北京市自然科学基金（Nos. 7131013、7142115），新药作用机制研究与药效评价北京市重点实验室资助项目（No. BZ0150），协和青年基金，中央级公益性科研院所基本科研业务费专项资金（No. 2014RC03）

Glial Cells Protect Neurons against Oxidative Stress in Huntington’s Disease

GAO Yan, CHU Shi-feng, CHEN Nai-hong

State Key Laboratory of Bioactive Substances and Functions of Natural Medicines, Department of Pharmacology, Institute of Materia Medica & Neuroscience Center, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100050, China

Online:2014-06-26 Published:2015-01-20
Contact: 陈乃宏，男，研究员，博士生导师；研究方向：神经精神药理学；Tex/Fax：010-63165182，010-63165177，E-mail：chennh@imm.ac.cn
About author:高岩，女，博士研究生；研究方向：神经精神药理学；E-mail：gaoyan@imm.ac.cn
Supported by:
国家自然科学基金项目（Nos. 81274122、81102831、81173578、81202507、81273629、81373510），国家“重大新药创制”科技重大专项（Nos. 2012ZX09301002-004、2012ZX09103101-006），国家高技术研究发展计划（863 计划）（No. 2012AA020303），教育部长江学者和创新团队发展计划（PCSIRT）（No. IRT1007），教育部博士点基金重点项目（No. 20121106130001），北京市自然科学基金（Nos. 7131013、7142115），新药作用机制研究与药效评价北京市重点实验室资助项目（No. BZ0150），协和青年基金，中央级公益性科研院所基本科研业务费专项资金（No. 2014RC03）

摘要/Abstract

摘要： 氧化应激的产生与胞浆内活性氧簇的升高密切相关，过多生成的活性氧簇能够造成脂质过氧化，损伤蛋白质甚至DNA，而这些物质的受损与疾病发生相关，尤其是神经退行性疾病。神经退行性疾病经常被描述为进行性的神经元丢失，伴随神经元或者胶质细胞中出现标志性寡聚体。在神经退行性疾病中，胶质细胞可能以一种抗氧化应激的方式在神经元功能维持以及生存上发挥重要作用。反之，神经元也能够通过不同途径反馈调节胶质细胞。在这篇综述里，我们主要探讨在亨廷顿舞蹈症中胶质细胞的特点和功能，阐明氧化应激与亨廷顿舞蹈症的关系，概括这三者之间的关系进而论证胶质细胞在亨廷顿舞蹈症中的抗氧化应激保护作用。

关键词: 胶质细胞, 神经元, 氧化应激, 亨廷顿舞蹈症

Abstract: Oxidative stress refers to elevated intracellular levels of reactive oxygen species (ROS) which cause damage to lipids, proteins and DNA. Changes in these macromolecules are involved in myriad pathological changes and progression of diseases, especially neurodegenerative diseases (NDD). NDD are usually featured by progressive neuron loss, accompanied with inclusions in neurons or glial cells. In NDD, glial cells may play a vital role in the functioning of neurons and cellular survival through an antioxidant way. Conversely, neurons could modulate the activities of glia in different ways. In this review, the main purposes were to summarize the characteristics and functions of glial cells in Huntington’s disease (HD). The connection between oxidative stress and HD, and state the cross talk between these interactive elements were also discussed.

Key words: glial cells, neurons, oxidative stress, Huntington&, rsquo, s disease

中图分类号:

R964

高岩, 楚世峰, 陈乃宏. 亨廷顿舞蹈症、氧化应激与胶质细胞[J]. 神经药理学报, 2014, 4(3): 22-30.

GAO Yan, CHU Shi-feng, CHEN Nai-hong. Glial Cells Protect Neurons against Oxidative Stress in Huntington’s Disease[J]. Acta Neuropharmacologica, 2014, 4(3): 22-30.

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