ACTA NEUROPHARMACOLOGICA ›› 2024, Vol. 14 ›› Issue (4): 29-.DOI: 10.3969/j.issn.2095-1396.2024.04.005

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To Observe the Effect of Yishen-Buganjiangu Decoction Combined with Ecalcitonin in the Treatment of Primary Osteoporosis and Its Influence on Bone Metabolism and Oxidative Stress

DAI Xiu-xia,LIN Hai-yang,SU Zi-zhen,QIU Ying-jie,SU Li-yun,CHEN Li-feng   

  1. 1. Third Department of Tuina Therapy, Xiamen Hospital of Traditional Chinese Medicine, Xiamen, 361100, China 

    2. Department of Traditional Chinese Medicine, 73rd Group Army Hospital, Xiamen, 361100, China 

    3. Department of Rehabilitation, Ninghua Hospital of Traditional Chinese Medicine, Sanming, 365499, China 

    4. Department of TCM Diagnosis and Treatment, Xiamen Hospital of Traditional Chinese Medicine, Xiamen, 361100, China

  • Online:2024-08-26 Published:2025-01-04

Abstract:

Objective: To investigate the effect of Yishen-Buganjiangu decoction combined with ecalcitonin on primary osteoporosis and its influence on bone metabolism and oxidative stress. Methods: Eighty patients with osteoporosis were divided into a control group and an observation group. The control group received intramuscular injection of ecalcitonin, 10 IU·time-1, twice a week. The observation group was treated with Yishen Bugan Jiangu decoction on the basis of the control group. Both groups were treated for 6 months. The curative effect, bone mineral density, bone pain [visual analogue scale (VAS)], bone metabolism index [procollagen type Ⅰ N-terminal propeptide (PINP), type I C-terminal cross linked peptide (CTX-1), serum oxidative stress markers [malondialdehyde (MDA) and advanced oxidation protein product (AOPP)]before and after treatment were compared between the two groups. Results: After treatment, the total effective rate of the observation group was higher than that of the control group (97.50% vs 82.50%, P<0.05), and the VAS score was lower than that of the control group (P<0.05). After treatment, PINP increased in the two groups (P<0.05), and it was higher in the observation group (P<0.05). The levels of CTX-1 in the two groups were decreased (P<0.05), and the level in the observation group was lower (P<0.05). There was no significant difference in the incidence of adverse reactions between the two groups (P>0.05). Conclusion: Yishen Bugan Jiangu Decoction combined with western medicine is effective in the treatment of primary osteoporosis, which can improve bone metabolism and oxidative stress.

Key words: primary osteoporosis, calcitonin, Yishen Bugan Jiangu decoction, bone metabolism, oxidative stress

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