Discussed the Application of Curcumin Combined with Piperine Based on the Metabolic Characteristics of Curcumin

doi:10.3969/j.issn.2095-1396.2019.06.010

Abstract

Abstract:

Curcumin is a yellow acid phenolic substance with anti-tumor，anti-oxidation， anti-inflammatory and anti-fibrosis pharmacological effects，but its low bioavailability has always limited the development and utilization of curcumin. Piperine and cinnamolphthalein alkaloids have good safety，and can increase the bioavailability of curcumin by inhibiting multiple drug metabolic enzymes and transporters，thus increasing its pharmacological effects in many aspects. Using new preparation technology to encapsulate curcumin and piperine in special carrier materials can endow drugs with new properties，such as increased solubility，improved stability and drug targeting，so as to further increase the therapeutic effect of curcumin.The aim of this paper is to summarize the molecular and metabolic characteristics of curcumin，to discuss the mechanism of piperine increasing its pharmacological action from the metabolic perspective， and to summarize the research status of combined use of curcumin and piperine，so as to provide reference for future scientific research.

Key words: curcumin, piperine, combination therapy, bioavailability

CLC Number:

R964

LIANG Yu-fei，ZHANG Xin-xin，ZHAO Li-yan，et al. Discussed the Application of Curcumin Combined with Piperine Based on the Metabolic Characteristics of Curcumin[J]. Acta Neuropharmacologica, DOI: 10.3969/j.issn.2095-1396.2019.06.010.

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