Research Status of the Drugs Uesed in the Treatment of Affective Disorders Diseases

Abstract

Abstract: Affective disorders including depression (also known as unipolar depression) and bipolar disorder (unipolar depression)，are the most common psychiatric disorders, which have high incidence ratio, high recurrence ratio, and is harmful to the society. Clinically, anti-unipolar depression drugs are mainly serotonin-specific reuptake inhibitors (SSRIs), fluoxetine as represented, and serotonin/norepinephrine dual reuptake inhibitor (SNRIs), duloxetine as represented. And lithium salts (Li⁺), valproate sodium, and carbamazepine are the three classical anti-bipolar drugs. At present, researches concerning these drugs propose following major mechanisms: ①The expression of cytosolic phospholipase A2 (cPLA₂), extracellular-signal regulated kinases (ERK) and c-Fos and FosB is increased by SSRIs; ②Chronic administration of Fluoxetine could induce 5-HT_2B receptor pre-mRNA editing, with the help of adenosine deaminase (ADAR2) activity; ③Lithium carbonate, carbamazepine, valproate sodium could upregulate the mRNA and protein of cPLA_2a and induce alkalinization of cell. But the accurate pharmacological mechanisms of these drugs have not been fully elucidated and are needed to be further investigated.

Key words: depression, serotonin-specific reuptake inhibitors (SSRIs), lithium carbonate, carbamazepine, valproate sodium, cytosolic phospholipase A₂ (cPLA₂), adenosine deaminase (ADAR₂), intracellular alkalinization

CLC Number:

XUE Zhan-xia, PENG Liang. Research Status of the Drugs Uesed in the Treatment of Affective Disorders Diseases[J]. ACTA NEUROPHARMACOLOGICA, 2011, 1(3): 55-64.

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Research Status of the Drugs Uesed in the Treatment of Affective Disorders Diseases

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