Parkinson Associated DJ-1 Gene and Oxidative Stress

doi:10.3969/j.issn.2095-1396.2016.01.008

Abstract

Abstract: Parkinson’s disease is characterized by the substantia nigra pars compacta dopaminergic neuron-specific death and the presence of eosinophilic inclusion bodies-Lewy bodies which’s main component is α- synuclein in residual neuronal. Recent studies show that oxidative stress is a leading cause of brain dopaminergic neuron-specific death. DJ-1 （Park7） gene is an autosomal recessive Parkinson’s disease related genes. DJ-1 protein has a strong antioxidant effect，mainly acts as identity of active oxygen scavenger，chaperones，signaling pathways regulating molecules to against the oxidative stress，thereby protecting dopamine neurons from damage. Both deletion and mutation of DJ-1 gene will cause the reduction of its anti-oxidative stress，resulting in neuronal death，and this situation may be rescued by overexpression of DJ-1 protein. Because of the important role of DJ-1 in the development and occurrence of Parkinson’s disease，the paper will expand on its review of new research，and discuss primarily from the relationship between DJ-1 and oxidative stress.

Key words: Parkinson&, rsquo, s disease（PD）, DJ-1, oxidative stress, reactive oxygen species（ROS）

CLC Number:

R964

LOU Yu-xia, ZHANG Zhao, WANG Zhen-zhen, JIANG Yi-na, ZHANG Yi, LI Lin, CHEN Nai-hong. Parkinson Associated DJ-1 Gene and Oxidative Stress[J]. ACTA NEUROPHARMACOLOGICA, 2016, 6(1): 58-64.

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