ACTA NEUROPHARMACOLOGICA ›› 2016, Vol. 6 ›› Issue (1): 58-64.DOI: 10.3969/j.issn.2095-1396.2016.01.008

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Parkinson Associated DJ-1 Gene and Oxidative Stress

LOU Yu-xia,ZHANG Zhao,WANG Zhen-zhen,JIANG Yi-na,ZHANG Yi,LI Lin,CHEN Nai-hong   

  1. 1. Tianjin University of Traditional Chinese Medicine,Tianjin,300193,China
    2. Neuroscience Center,Institute of Materia Medica,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing,100050,China
    3. Hunan University of Chinese Medicine,Changsha,410208,China
    4. Beijing University of Chinese Medicine Basic Medical Anatomy,Beijing,100029,China
    5. Key Laboratory of Neurodegenerative Diseases of Minstry of Education (Capital Medical University),Beijing,100069,China
  • Online:2016-02-26 Published:2016-05-10
  • Contact: 陈乃宏,男,研究员,博士生导师;研究方向:分子神经药理学、中药药理学;Tel/Fax:+86-010-63165177,E-mail:chennh@imm.ac.cn
  • About author:娄钰霞,女,硕士研究生;研究方向:神经药理学和神经生物学;E-mail:353323371@qq.com
  • Supported by:

    国家自然科学基金项目(No.81274122、No.81373997、No.81273629、No.81473376、No.U1402221、No.81573640),北京市自然科学基金项目(No.7131013、No.7161011),新药作用机制研究与药效评价北京市重点实验室资助项目(No.BZ0150),神经变性病教育部重点实验室开放研究课题(No.2016SJBX03),湖南省重点研发计划项目(No.2015SK2029-1),湖南省教育厅高校科研经费开放基金项目(No.15K091)

Abstract: Parkinson’s disease is characterized by the substantia nigra pars compacta dopaminergic neuron-specific death and the presence of eosinophilic inclusion bodies-Lewy bodies which’s main component is α- synuclein in residual neuronal. Recent studies show that oxidative stress is a leading cause of brain dopaminergic neuron-specific death. DJ-1 (Park7) gene is an autosomal recessive Parkinson’s disease related genes. DJ-1 protein has a strong antioxidant effect,mainly acts as identity of active oxygen scavenger,chaperones,signaling pathways regulating molecules to against the oxidative stress,thereby protecting dopamine neurons from damage. Both deletion and mutation of DJ-1 gene will cause the reduction of its anti-oxidative stress,resulting in neuronal death,and this situation may be rescued by overexpression of DJ-1 protein. Because of the important role of DJ-1 in the development and occurrence of Parkinson’s disease,the paper will expand on its review of new research,and discuss primarily from the relationship between DJ-1 and oxidative stress.

Key words: Parkinson&, rsquo, s disease(PD), DJ-1, oxidative stress, reactive oxygen species(ROS)

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