Research Progress on the Protective Eff ect of Cerebral Ischemia Preconditioning on Cerebral Ischemia Injury

Abstract

Abstract: Cerebral ischemic preconditioning（ CIP） is a method of endogenous mechanical stimulation of cerebral tissue，such as inducing the reperfusion stimulation by once，or repeatedly transient cerebral ischemia and non-fatal cerebral ischemia. In this way the cerebral tissue will produce the endogenesis defense mechanism.The cerebral tissue will generate significant tolerance of lethal ischemia，and weaken or block the cascade reaction induced by cerebral ischemia or cerebral anoxia. And this phenomenon is also called cerebral ischemia tolerance （CIT）. Cerebral ischemia-reperfusion injury（CIRI） is a physiological process of clinical pathology that is involoved in multipal mechanism. It could further aggravate the extent of cerebral tissue damage and dysfunction，and even irreversible damage occurs after restoration of blood flow and reperfusion. All in all，CIP plays a protective role to CIRI. This review will summarize the related neural protection mechanism and important pathways about CIP for CIRI protection.

Key words: cerebral ischemia preconditioning, ischemia-reperfusion injury, autophagy, inflammation, calcium overload

ZHANG Jing, ZOU Yu-an, Dong Xiao-hua. Research Progress on the Protective Eff ect of Cerebral Ischemia Preconditioning on Cerebral Ischemia Injury[J]. Acta Neuropharmacologica, 2015, 5(5): 57-64.

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