Recent Advance on Sleep-Wake Regulation Based on Novel Techniques for Specific Manipulations of Neuron Activities

doi:10.3969/j.issn.2095-1396.2018.01.004

Abstract

Abstract: One-third of life is spent in sleep，but why we need to sleep and how sleep-wake cycles regulate are still mysterious. The previous used pharmacology，
immunohistochemistry，neuronal damage and other traditional research methods have partly revealed several brain areas related to sleep-wake . As it familiar to us that hypothalamic ventrolateral preoptic area and parafacial zone are sleep-promoting areas，while the midbrain dorsal raphe，locus coeruleus，tuberomammillary nucleus，lateral hypothalamus and basal forebrain wake-promoting areas. Though these brain regions that regulate sleep-wake are interacting，they also closely linked to maintain normal sleep-wake cycles. However，due to the poor spatial specificity and selectivity by traditional technology，it is tough to accurately explore more new sleep-wake related brain areas and neurons. In recent years，with the application of specific manipulation of neuron activity，researchers can specifically control different kinds of neuronal activities in the brain，including GABAergic，glutamatergic，and cholinergic neurons to study their roles in sleep-wake regulations，or to identify new brain regions. This review focuses on the new progress in the study of sleep-wake regulation mechanism based on optogenetic and chemogenetic techniques.

Key words: chemogenetics, Cre-mice, optogenetics, sleep-wake cycle

CLC Number:

R964

YANG Yan-fei，HUANG Zhi-li. Recent Advance on Sleep-Wake Regulation Based on Novel Techniques for Specific Manipulations of Neuron Activities[J]. Acta Neuropharmacologica, 2018, 8(1): 23-34.

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