Advances in Parkinson’s Disease-Causing Gene Parkin

Abstract

Abstract: In the global neurodegenerative diseases，the incidence of Parkinson is second only to Alzheimer’s disease. Parkin is one of the gene which associated with Parkinson’s disease. Since the hypothesis that Parkin is associated with the Parkinson’s disease was confirmed by Japannese scholar，the researches about it were developed rapidly. The basic structure，physiological function，the protein substrates and related genes，accompanied their pathogenic mechanisms of Parkin have been reported in numerous literature. This paper describes the structure and protein of Parkin，reviews Parkin and its ubiquitin-protein enzyme system in detail，describes the relationship between Parkin and that the relevant reactants and mitochondria，and proposes ideas for their development prospects.

Key words: Parkin, Parkinson&, rsquo, s disease, Substrates, Gene mutation, Ubiquitination

CLC Number:

R964

JIANG Yi-na, CHEN Nai-hong. Advances in Parkinson’s Disease-Causing Gene Parkin[J]. ACTA NEUROPHARMACOLOGICA, 2015, 5(3): 36-45.

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