The Research Progress of Adrenaline Receptor and its Signal Involved in the Regulation on Nerve Immunity in Rheumatoid Arthritis

Abstract

Abstract: The etiology of rheumatoid arthritis（ RA） has not been fully elucidated，but the mental factors may be involved in the pathogenesis of RA. These factors regulated the immune function of RA by affecting the hypothalamus-pituitary-adrenal axis and the sympathetic nervous system. Adrenergic receptor（ AR） is the key receptors which plays a role on regulating neural immune function，and it may be involved in the occurrence and development of RA. This review
includes the classification and characteristics of AR，its ligand expression and function in RA，and the regulation of AR on the key immune cells，such as T and B lymphocytes，etc. This review will help understand the research progress of AR and its signal in RA.

Key words: rheumatoid arthritis, adrenergic receptor, norepinephrine, stress

CLC Number:

R593.22

WU Hua-xun，WEI Wei. The Research Progress of Adrenaline Receptor and its Signal Involved in the Regulation on Nerve Immunity in Rheumatoid Arthritis[J]. Acta Neuropharmacologica, 2015, 5(1): 59-64.

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