Progress in the Relationship of Adult Hippocampal Neurogenesis and Alzheime’s Disease

Abstract

Abstract: Neurogenesis occurs throughout the adulthood in mammals, which involves neural stem cell proliferation, migration, differentiation and integration into the circuits. Alzheimer's disease (AD) is a progressive neurodegenerative disorder, characterized in the brain by amyloid plaque deposits, neurofibrillary tangles and neuronal loss. In recent years, evidence indicates that adult hippocampal neurogenesis provides new opportunities for the treatment for AD. Here we review recent progress on the relationship between adult hippocampal neurogenesis and AD.

Key words: hippocampus, neurogenesis, Alzheimer's disease

CLC Number:

R338

HE Na, YIN Ming, WANG Ze-jian. Progress in the Relationship of Adult Hippocampal Neurogenesis and Alzheime’s Disease[J]. Acta Neuropharmacologica, 2013, 3(6): 25-32.

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