Research Advances on Fate Decision of NSCs and Its Potential Target Modulation

Abstract

Abstract: Neural stem cells (NSCs) are the source of neurons, oligodendrocytes and astrocytes in mammal neural system. In recent years, study base on the mechanisms of NSCs differentiation，proliferation and clinic research on neural degeneration diseases have been held great interests. Multiple cell regulation factors in the microenvironment co-regulate the self-renewal, differentiation and migration of NSCs. Among the factors, Notch，NF-κB and Wnt have been called “fate decision makers” and gained extensive attention. Each of them can control either differentiation or proliferation on their own. Here we reviewed the mechanisms of fate decision of three major signaling pathways: Notch, Wnt and NF-kB and summarized the potential drug targets and exogenous regulation factors, hoping to provide some guidance for future stem cell research.

Key words: neural stem cell, fate decision, notch, wnt, NF-kB

CLC Number:

R964

MA Yin-zhong, CHEN Nai-hong. Research Advances on Fate Decision of NSCs and Its Potential Target Modulation[J]. ACTA NEUROPHARMACOLOGICA, 2012, 2(3): 37-42.

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