Acta Neuropharmacologica ›› 2012, Vol. 2 ›› Issue (1): 45-64.
ZHAO Jun,WANG Jin-hui
Online:2012-02-26
Published:2013-05-06
Contact:
王晋辉，男，研究员，博士生导师；研究方向：神经生理学和神经药理学；联系电话：86-10-64888472，传真：86-10-64871293，Email：jhw@sun5.ibp.ac.cn
About author:赵君，男，中国科学院生物物理研究所博士生；联系电话：86-10-64862572，Email：zhaojun0701@msn.com
Supported by:国家重点基础研究发展计划（973）基金(N2011CB504405) ，国家自然科学基金 (30990261 和 81171033)
CLC Number:
ZHAO Jun,WANG Jin-hui. In Vivo Application of Two-photon Microscopy in Neuropharmacological Research[J]. Acta Neuropharmacologica, 2012, 2(1): 45-64.
| [1] Göppert-Mayer Maria. Über Elementarakte mit zwei quantensprüngen [J]. Annalen der Physik, 1931, 401(3): 273-294. [2] Kaiser W, Garrett C G B. 2-Photon Excitation in CaF2 - Eu2+ [J]. Physical Review Letters, 1961, 7(6): 229-231.[3] Abella I D. Optical double-photon absorption in cesium vapor [J]. Physical Review Letters, 1962, 9(11): 453.[4] Berns M W. Possible 2-photon effect in vitro using a focused laser-beam [J]. Biophysical Journal, 1976, 16(8): 973-977.[5] Denk W, Strickler J H, Webb W W. Two-photon laser scanning fluorescence microscopy [J]. Science, 1990, 248(4951): 73-76.[6] Winfried Denk, Karel Svoboda. Photon upmanship: why multiphoton imaging is more than a gimmick [J]. Neuron, 1997, 18(3): 351-357.[7] Fritjof Helmchen, Winfried Denk. Deep tissue two-photon microscopy [J]. Nat Methods, 2005, 2(12): 932-940.[8] Brian A Wilt, Laurie D Burns, Eric Tatt Wei Ho, et al. Advances in light microscopy for neuroscience [J]. Annu Rev Neurosci, 2009, 32: 435-506.[9] Warren R Zipfel, Rebeca M Williams, Watt W Webb. Nonlinear magic: multiphoton microscopy in the biosciences [J]. Nat Biotechnol, 2003, 21(11): 1369-1377.[10] Alberto Diaspro, Giuseppe Chirico, Maddalena Collini. Two-photon fluorescence excitation and related techniques in biological microscopy [J]. Q Rev Biophys, 2005, 38(2): 97-166.[11] Padmanabhan K, Andrews S E, Fitzpatrick J A. Multi-photon imaging [J]. Curr Protoc Cytom, 2010, Chapter 2: Unit 29.[12] Axel Nimmerjahn, Frank Kirchhoff, Jason N D Kerr, et al. Sulforhodamine 101 as a specific marker of astroglia in the neocortex in vivo [J]. Nat Methods, 2004, 1(1): 31-37.[13] Karel Svoboda, Winfried Denk, David Kleinfeld, et al. In vivo dendritic calcium dynamics in neocortical pyramidal neurons [J]. Nature, 1997, 385(6612): 161-165.[14]Emily A Gibson, Omid Masihzadeh, Tim C Lei, et al. Multiphoton microscopy for ophthalmic imaging [J]. JOphthalmol, 2011, 2011 ,doi:10.1155/2011/870879.[15] Grace E Stutzmann, Ian Parker. Dynamic multiphoton imaging: A live view from cells to systems [J]. Physiology(Bethesda), 2005, 20: 15-21.[16] Yoshikazu Imanishi, Kerrie H Lodowski, Yiannis Koutalos. Two-photon microscopy: shedding light on the chemistry of vision [J]. Biochemistry, 2007, 46(34): 9674-9684.[17] Peter T So, Chen Y Dong, Barry R Masters, et al. Two-photon excitation fluorescence microscopy [J]. Annu Rev Biomed Eng, 2000, 2: 399-429.[18] Norio Takata, Hajime Hirase. Cortical layer 1 and layer 2/3 astrocytes exhibit distinct calcium dynamics in vivo [J]. PLoS ONE, 2008, 3(6): e2525.[19] Nimmerjahn A, Kirchhoff F, Helmchen F. Resting microglial cells are highly dynamic surveillants of brain parenchyma in vivo [J]. Science, 2005, 308(5726): 1314-1318.[20] Hiroaki Wake, Andrew J Moorhouse, Shozo Jinno, et al. Resting microglia directly monitor the functional state of synapses in vivo and determine the fate of ischemic terminals [J]. J Neurosci, 2009, 29(13): 3974-3980.[21] Hiroyuki Inada, Miho Watanabe, Taku Uchida, et al. GABA regulates the multidirectional tangential migration of GABAergic interneurons in living neonatal mice [J]. PLoS ONE, 2011, 6(12): e27048.[22] Graham C R Ellis-Davies. Two-photon microscopy for chemical neuroscience [J]. Acs Chemical Neuroscience, 2011, 2(4): 185-197.[23] Jamie Grutzendler, Narayanan Kasthuri, Wen-Biao Gan. Long-term dendritic spine stability in the adult cortex [J]. Nature, 2002, 420(6917): 812-816.[24] Joshua T Trachtenberg, Brian E Chen, Graham W Knott, et al. Long-term in vivo imaging of experience-dependent synaptic plasticity in adult cortex [J]. Nature, 2002, 420(6917): 788-794.[25] Xu Tong-hui, Yu Xin-zhu, Andrew J Perlik, et al. Rapid formation and selective stabilization of synapses for enduring motor memories [J]. Nature, 2009, 462(7275): 915-919.[26] Dan D Stettler, Homare Yamahachi, Li Wu, et al. Axons and synaptic boutons are highly dynamic in adult visual cortex [J]. Neuron, 2006, 49(6): 877-887.[27] Ania K Majewska, Jessica R Newton, Mriganka Sur. Remodeling of synaptic structure in sensory cortical areas in vivo [J]. J Neurosci, 2006, 26(11): 3021-3029.[28] Carlos Portera-Cailliau, Robby M Weimer, Vincenzo De Paola, et al. Diverse modes of axon elaboration in the developing neocortex [J]. PLoS Biol, 2005, 3(8): e272.[29] Hiroshi Nishiyama, Masahiro Fukaya, Masahiko Watanabe, et al. Axonal motility and its modulation by activity are branch-type specific in the intact adult cerebellum [J]. Neuron, 2007, 56(3): 472-487.[30] Jerome Ruel, Christian Chabbert, Regis Nouvian, et al. Salicylate enables cochlear arachidonic-acid-sensitive NMDA receptor responses [J]. J Neurosci, 2008, 28(29): 7313-7323.[31] Martin Fuhrmann, Tobias Bittner, Christian K E Jung, et al. Microglial Cx3cr1 knockout prevents neuron loss in a mouse model of Alzheimer's disease [J]. Nat Neurosci, 2010, 13(4): 411-413.[32] Payam Dibaj, Fabien Nadrigny, Heinz Steffens, et al. NO mediates microglial response to acute spinal cord injury under ATP control in vivo [J]. Glia, 2010, 58(9): 1133-1144.[33] James D Jontes, Michelle R Emond, Stephen J Smith. In vivo trafficking and targeting of N-cadherin to nascent presynaptic terminals [J]. J Neurosci, 2004, 24(41): 9027-9034.[34] Michael J Boulware, Jonathan S Marchant. Timing in cellular Ca2+ signaling [J]. Curr Biol, 2008, 18(17): R769-R776.[35] Michael J Berridge. Neuronal calcium signaling [J]. Neuron, 1998, 21(1): 13-26.[36] Michael J Berridge, Martin D Bootman, H Llewelyn Roderick. Calcium signalling: dynamics, homeostasis and remodelling [J]. Nat Rev Mol Cell Biol, 2003, 4(7): 517-529.[37] Michael J Berridge, Peter Lipp, Martin D Bootman. The versatility and universality of calcium signalling [J]. Nat Rev Mol Cell Biol, 2000, 1(1): 11-21.[38] Katz B, Miledi R. The role of calcium in neuromuscular facilitation [J]. J Physiol, 1968, 195(2): 481-492.[39] Ole H Petersen, Marek Michalak, Alexei Verkhratsky. Calcium signalling: past, present and future [J]. Cell Calcium, 2005, 38(3-4): 161-169.[40] Joshua T Vogelstein, Adam M Packer, Timothy A Machado, et al. Fast non-negative deconvolution for spike train inference from population calcium imaging [J]. J Neurophysiol, 2010, 104(6): 3691–3704.[41] Joshua T Vogelstein, Brendon O Watson, Adam M Packer, et al. Spike inference from calcium imaging using sequential Monte Carlo methods [J]. Biophys J, 2009, 97(2): 636-655.[42] Emre Yaksi, Rainer W Friedrich. Reconstruction of firing rate changes across neuronal populations by temporally deconvolved Ca2+ imaging [J]. Nat Methods, 2006, 3(5): 377-383.[43] Cendra Agulhon, Jeremy Petravicz, Allison B McMullen, et al. What is the role of astrocyte calcium in neurophysiology? [J]. Neuron, 2008, 59(6): 932-946.[44] Todd A Fiacco, Cendra Agulhon, Ken D McCarthy. Sorting out astrocyte physiology from pharmacology [J]. Annu Rev Pharmacol Toxicol, 2009, 49: 151-174.[45] Axel Nimmerjahn. Astrocytes going live: advances and challenges [J]. J Physiol, 2009, 587(Pt 8): 1639-1647.[46] Doris D Wang, Angelique Bordey. The astrocyte odyssey [J]. Prog Neurobiol, 2008, 86(4): 342-367.[47] Roger Y Tsien. New calcium indicators and buffers with high selectivity against magnesium and protons: design, synthesis, and properties of prototype structures [J]. Biochemistry, 1980, 19(11): 2396-2404.[48] Tsien R Y. A non-disruptive technique for loading calcium buffers and indicators into cells [J]. Nature, 1981, 290(5806): 527-528.[49] Loren L Looger, Oliver Griesbeck. Genetically encoded neural activity indicators [J]. Curr Opin Neurobiol, 2012, 22(1): 18-23.[50] Christine Grienberger, Arthur Konnerth. Imaging calcium in neurons [J]. Neuron, 2012, 73(5): 862-885.[51] Karel Svoboda, Ryohei Yasuda. Principles of two-photon excitation microscopy and its applications to neuroscience [J]. Neuron, 2006, 50(6): 823-839.[52] Jens Eilers, Arthur Konnerth. Dye loading with patch pipettes [J]. Cold Spring Harb Protoc, 2009, 2009(4): pdb.prot5201.[53] Shin Nagayama, Shapqun Zeng, Wenhui Xiong, et al. In vivo simultaneous tracing and Ca(2+) imaging of local neuronal circuits [J]. Neuron, 2007, 53(6): 789-803.[54] Christoph Stosiek, Olga Garaschuk, Knut Holthoff, et al. In vivo two-photon calcium imaging of neuronal networks [J]. Proc Natl Acad Sci USA, 2003, 100(12): 7319-7324.[55] Olga Garaschuk, Ruxandra I Milos, Arthur Konnerth. Targeted bulk-loading of fluorescent indicators for two-photon brain imaging in vivo [J]. Nat Protoc, 2006, 1(1): 380-386.[56] Garaschuk O, Konnerth A. In vivo two-photon calcium imaging using multicell bolus loading [J]. Cold Spring Harb Protoc, 2010, 2010(10): pdb.prot5482.[57] Werner Gobel, Fritjof Helmchen. In vivo calcium imaging of neural network function [J]. Physiology (Bethesda), 2007, 22(6): 358-365.[58] Osamu Shimomura, Frank H Johnson, Yo Saiga. Extraction, purification and properties of aequorin, a bioluminescent protein from the luminous hydromedusan, Aequorea [J]. J Cell Comp Physiol, 1962, 59(3): 223-239.[59] Rink T J, Tsien R Y, Warner A E. Free calcium in Xenopus embryos measured with ion-selective microelectrodes [J]. Nature, 1980, 283(5748): 658-660.[60] Sharba Bandyopadhyay, Shihab A Shamma, Patrick O. Kanold Dichotomy of functional organization in the mouse auditory cortex [J]. Nat Neurosci, 2010, 13(3): 361-368.[61] Ryohei Yasuda, Esther A Nimchinsky, Volker Scheuss, et al. Imaging calcium concentration dynamics in small neuronal compartments [J]. Sci STKE, 2004, 2004(219): pl5.[62] Gideon Rothschild, Israel Nelken, Adi Mizrahi. Functional organization and population dynamics in the mouse primary auditory cortex [J]. Nat Neurosci, 2010, 13(3): 353-360. [63] Zsuzsanna Varga, Hongbo Jia, Bert Sakmann, et al. Dendritic coding of multiple sensory inputs in single cortical neurons in vivo [J]. Proc Natl Acad Sci USA, 2011, 108(37): 15420-15425.[64] Kazuo Kitamura, Michael Hausser. Dendritic calcium signaling triggered by spontaneous and sensory-evoked climbing fiber input to cerebellar Purkinje cells in vivo [J]. J Neurosci, 2011, 31(30): 10847-10858.[65] Wolfgang Mittmann, Damian J Wallace, Uwe Czubayko, et al. Two-photon calcium imaging of evoked activity from L5 somatosensory neurons in vivo [J]. Nat Neurosci, 2011, 14(8): 1089-1093.[66] Serge Charpak, Jerome Mertz, Emmanuel Beaurepaire, et al. Odor-evoked calcium signals in dendrites of rat mitral cells [J]. Proc Natl Acad Sci USA, 2001, 98(3): 1230-1234.[67] Fritjof Helmchen, Karel Svoboda, Winfried Denk, et al. In vivo dendritic calcium dynamics in deep-layer cortical pyramidal neurons [J]. Nat Neurosci, 1999, 2(11): 989-996.[68] Karel Svoboda, Fritjof Helmchen, Winfried Denk, et al. Spread of dendritic excitation in layer 2/3 pyramidal neurons in rat barrel cortex in vivo [J]. Nat Neurosci, 1999, 2(1): 65-73.[69] Jia Hong-bo, Nathalie L Rochefort, Chen Xiao-wei, et al. In vivo two-photon imaging of sensory-evoked dendritic calcium signals in cortical neurons [J]. Nat Protoc, 2011, 6(1): 28-35.[70] Chen Xiao-wei, Ulrich Leischner, Nathalie L Rochefort, et al. Functional mapping of single spines in cortical neurons in vivo [J]. Nature, 2011, 475(7357): 501-505.[71] Agens Bonnot, George Z Mentis, Jesse Skoch, et al. Electroporation loading of calcium-sensitive dyes into the CNS [J]. J Neurophysiol, 2005, 93(3): 1793-1808.[72] Kazuhiro Sohya, Katsuro Kameyama, Yuchio Yanagawa, et al. GABAergic neurons are less selective to stimulus orientation than excitatory neurons in layer II/III of visual cortex, as revealed by in vivo functional Ca2+ imaging in transgenic mice [J]. J Neurosci, 2007, 27(8): 2145-2149.[73] James Schummers, Yu Hong-bo, Sur Mriganka. Tuned responses of astrocytes and their influence on hemodynamic signals in the visual cortex [J]. Science, 2008, 320(5883): 1638-1643.[74] Kenichi Ohki, R Clay Reid. Specificity and randomness in the visual cortex [J]. Curr Opin Neurobiol, 2007, 17(4): 401-407.[75] Kenichi Ohki, Sooyoung Chung, Yeang H, Ch'ng et al. Functional imaging with cellular resolution reveals precise micro-architecture in visual cortex [J]. Nature, 2005, 433(7026): 597-603.[76] Takashi R Sato, Noah W Gray, Zachary F Mainen, et al. The functional microarchitecture of the mouse barrel cortex [J]. PLoS Biol, 2007, 5(7): e189.[77] Jason N D Kerr, Christiaan P de Kock, David S Greenberg, et al. Spatial organization of neuronal population responses in layer 2/3 of rat barrel cortex [J]. J Neurosci, 2007, 27(48): 13316-13328.[78] Wang Xiao-hai, Lou Nan-hong, Xu Qi-wu, et al. Astrocytic Ca2+ signaling evoked by sensory stimulation in vivo [J]. Nature neurosci, 2006, 9(6): 816-823.[79] Ian R Winship, Nathan Plaa, Timothy H Murphy. Rapid astrocyte calcium signals correlate with neuronal activity and onset of the hemodynamic response in vivo [J]. J Neurosci, 2007, 27(23): 6268-6272.[80] Chen Xiao-ke, Gabitto Mariano, Peng Yue-qing, et al. A gustotopic map of taste qualities in the mammalian brain [J]. Science, 2011, 333(6047): 1262-1266.[81] Dan D Stettler, Richard Axel. Representations of odor in the piriform cortex [J]. Neuron, 2009, 63(6): 854-864.[82] Jorn Niessing, Rainer W Friedrich. Olfactory pattern classification by discrete neuronal network states [J]. Nature, 2010, 465(7294): 47-52.[83] Megan R Sullivan, Axel Nimmerjahn, Dmitry V Sarkisov, et al. In vivo calcium imaging of circuit activity in cerebellar cortex [J]. J Neurophysiol, 2005, 94(2): 1636-1644.[84] Axel Nimmerjahn, Eran A Mukamel, Mark J Schnitzer. Motor behavior activates Bergmann glial networks [J]. Neuron, 2009, 62(3): 400-412.[85] Eran A Mukamel, Axel Nimmerjahn, Mark J Schnitzer. Automated analysis of cellular signals from large-scale calcium imaging data [J]. Neuron, 2009, 63(6): 747-760.[86] Hajime Hirase, Lifen Qian, Pater Bartho, et al. Calcium dynamics of cortical astrocytic networks in vivo [J]. PLoS Biol, 2004, 2(4): E96.[87] Takuya Sasaki, Nahoko Kuga, Shigehiro Namiki, et al. Locally synchronized astrocytes [J]. Cereb Cortex, 2011, 21(8): 1889-1900. [88] Maria Amalia Di Castro, Julien Chuquet, Nicolas Liaudet, et al. Local Ca(2+) detection and modulation of synaptic release by astrocytes [J]. Nature Neuroscience, 2011, 14(10): 1276-1287.[89] Gerhard Eichhoff, Bianca Brawek, Olga Garaschuk. Microglial calcium signal acts as a rapid sensor of single neuron damage in vivo [J]. Biochim Biophys Acta, 2011, 1813(5): 1014-1024.[90] Gerhard Eichhoff, Marc A Busche, Olga Garaschuk. In vivo calcium imaging of the aging and diseased brain [J]. Eur J Nucl Med Mol Imaging, 2008, 35 (Suppl 1): S99-106.[91] Helge C Johannssen, Fritjof Helmchen. In vivo Ca2+ imaging of dorsal horn neuronal populations in mouse spinal cord [J]. J Physiol, 2010, 588(Pt 18): 3397-3402.[92] Frederic Festy, Simon M Ameer-Beg, Tony Ng, et al. Imaging proteins in vivo using fluorescence lifetime microscopy [J]. Mol Biosyst, 2007, 3(6): 381-391.[93] Christian D Wilms, Hatmut Schmidt, Jens Eilers. Quantitative two-photon Ca2+ imaging via fluorescence lifetime analysis [J]. Cell Calcium, 2006, 40(1): 73-79.[94] Fritjof Helmchen, David Kleinfeld. Chapter 10 In vivo measurements of blood flow and glial cell function with two-photon laser-scanning microscopy [J]. Methods Enzymol, 2008, 444: 231-254.[95] David Kleinfeld, Partha P Mitra, Fritjof Helmchen, et al. Fluctuations and stimulus-induced changes in blood flow observed in individual capillaries in layers 2 through 4 of rat neocortex [J]. Proc Natl Acad Sci USA, 1998, 95(26): 15741-15746.[96] Andy Y Shih, Jonathan D Driscoll, Patrick J Drew, et al. Two-photon microscopy as a tool to study blood flow and neurovascular coupling in the rodent brain [J]. J Cereb Blood Flow Metab, 2012, 32(7): 1277-1309.[97] Benjamin B Scott, Timothy Gardner, Ni Ji, et al. Wandering neuronal migration in the postnatal vertebrate forebrain [J]. J Neurosci, 2012, 32(4): 1436-1446.[98] Dimitrios Davalos, Jae K Lee, W Bryan Smith, et al. Stable in vivo imaging of densely populated glia, axons and blood vessels in the mouse spinal cord using two-photon microscopy [J]. J Neurosci Methods, 2008, 169(1): 1-7.[99] Julien Chuquet, Pascale Quilichini, Esther A Nimchinsky, et al. Predominant enhancement of glucose uptake in astrocytes versus neurons during activation of the somatosensory cortex [J]. J Neurosci, 2010, 30(45): 15298-15303.[100] Sava Sakadzic, Emmanuel Roussakis, Mohammad A Yaseen, et al. Two-photon high-resolution measurement of partial pressure of oxygen in cerebral vasculature and tissue [J]. Nat Methods, 2010, 7(9): 755-759.[101] Anna Devor, Sava Sakadzic, Payam A Saisan, et al. "Overshoot" of O2 is required to maintain baseline tissue oxygenation at locations distal to blood vessels [J]. J Neurosci, 2011, 31(38): 13676-13681.[102] Sava Sakadzic, Emmanual Roussakis, Mohammad A Yaseen, et al. Cerebral blood oxygenation measurement based on oxygen-dependent quenching of phosphorescence [J]. J Vis Exp, 2011, 51, doi: 10.3791/1694. [103] Kovalchuk Y, Garaschuk O. Two-Photon chloride imaging using MQAE in vitro and in vivo [J]. Cold Spring Harb Protoc, 2012, 2012(7):778-785. [104] Kuan Hong Wang, Ania Majewska, James Schummers, et al. In vivo two-photon imaging reveals a role of arc in enhancing orientation specificity in visual cortex [J]. Cell, 2006, 126(2): 389-402. [105] Bart G Borghuis, Tian Lin, Xu Ying, et al. Imaging light responses of targeted neuron populations in the rodent retina [J]. J Neurosci, 2011, 31(8): 2855-2867.[106] Wei Tao, Timm Schubert, Francois Paquet-Durand, et al. Light-driven calcium signals in mouse cone photoreceptors [J]. J Neurosci, 2012, 32(20): 6981-6994.[107] Diana L Pettit, George J Augustine. Chemical two-photon uncaging [J]. CSH Protoc, 2007, 2007: pdb.prot4850.[108] Srinivas Kantevari, Judit K Makara, Attila Losonczy, et al. Development of anionically decorated 2-(ortho-nitrophenyl)-propyl-caged neurotransmitters for photolysis in vitro and in vivo [J]. Chembiochem, 2011, 12(3): 346[109] Jun Noguchi, Akira Nagaoka, Satoshi Watanabe, et al. In vivo two-photon uncaging of glutamate revealing the structure-function relationships of dendritic spines in the neocortex of adult mice [J]. J Physiol, 2011, 589(Pt 10): 2447-2457.[110] Edward S Boyden, Feng Zhang, Ernst Bamberg, et al. Millisecond-timescale, genetically targeted optical control of neural activity [J]. Nat Neurosci, 2005, 8(9): 1263-1268.[111] John Peter Rickgauer, David W Tank. Two-photon excitation of channelrhodopsin-2 at saturation [J]. Proc Natl Acad Sci USA, 2009, 106(35): 15025-15030.[112] Bertalan K Andrasfalvy, Boris V Zemelman, Jianyong Tang, et al. Two-photon single-cell optogenetic control of neuronal activity by sculpted light [J]. Proc Natl Acad Sci USA, 2010, 107(26): 11981-11986.[113] Hirase H, Nikolenko V, Yuste R. Multiphoton stimulation of neurons and spines [J]. Cold Spring Harb Protoc, 2012, 2012(4): pdb.prot068569.[114] Uday K Tirlapur, Karsten Konig. Targeted transfection by femtosecond laser [J]. Nature, 2002, 418(6895): 290-291.[115] Lindy E Barrett, Jai Yoon Sul, Hajime Takano, et al. Region-directed phototransfection reveals the functional significance of a dendritically synthesized transcription factor [J]. Nat Methods, 2006, 3(6): 455-460.[116] Vikram Kohli, Vanesa Robles, M Leonor Cancela, et al. An alternative method for delivering exogenous material into developing zebrafish embryos [J]. Biotechnol Bioeng, 2007, 98(6): 1230-1241.[117] Kelley D Sullivan, Edward B Brown. Multiphoton fluorescence recovery after photobleaching in bounded systems [J]. Phys Rev E Stat Nonlin Soft Matter Phys, 2011, 83(5): 051916.[118] Vivek K Unni, Tamliy A Weissman, Edward Rockenstein, et al. In vivo imaging of alpha-synuclein in mouse cortex demonstrates stable expression and differential subcellular compartment mobility [J]. PLoS One, 2010, 5(5): e10589.[119] Wu Tao, Samarendra Mohanty, Veronica Gomez-Godinez, et al. Neuronal growth cones respond to laser-induced axonal damage [J]. J R Soc Interface, 2012, 9(68): 535-547.[120] Daniel Stockholm, Marc Bartoli, Guillaume Sillon, et al. Imaging calpain protease activity by multiphoton FRET in living mice [J]. J Mol Biol, 2005, 346(1): 215-222.[121] Corentin Spriet, Dave Trinel, Frank Riquet, et al. Enhanced FRET contrast in lifetime imaging [J]. Cytometry A, 2008, 73(8): 745-753.[122] Eishu Hirata, Hiroko Yukinaga, Yuji Kamioka, et al. In vivo fluorescence resonance energy transfer imaging reveals differential activation of Rho-family GTPases in glioblastoma cell invasion [J]. J Cell Sci, 2012, 125(4): 858-868.[123] Amanda F Mower, Showming Kwok, Hongbo Yu, et al. Experience-dependent regulation of CaMKII activity within single visual cortex synapses in vivo [J]. Proc Natl Acad Sci USA, 2011, 108(52): 21241-21246.[124] Mattes Lahn, Carsten Dosche, Carsten Hille. Two-photon microscopy and fluorescence lifetime imaging reveal stimulus-induced intracellular Na+ and Cl- changes in cockroach salivary acinar cells [J]. Am J Physiol Cell Physiol, 2011, 300(6): C1323-1336.[125] Chang Ching-wei, Mary Ann Mycek. Precise fluorophore lifetime mapping in live-cell, multi-photon excitation microscopy [J]. Opt Express, 2010, 18(8): 8688-8696.[126] Carsten Hille, Mattes Lahn, Hans Gerd Lohmannsroben, et al. Two-photon fluorescence lifetime imaging of intracellular chloride in cockroach salivary glands [J]. Photochem Photobiol Sci, 2009, 8(3): 319-327.[127] Gael Moneron, Stefan W Hell. Two-photon excitation STED microscopy [J]. Opt Express, 2009, 17(17): 14567-14573.[128] Kazuo Kitamura, Benjamin Judkewitz, Masanobu Kano, et al. Targeted patch-clamp recordings and single-cell electroporation of unlabeled neurons in vivo [J]. Nat Methods, 2008, 5(1): 61-67.[129] Kazuo Kitamura. Two-photon targeted patch-clamp recordings in vivo [J]. Patch Springer Protocols Handbooks, 2012, 61: 183-193.[130] Kitamura K. Prospect of in vivo targeted whole-cell recording using two-photon microscopy [J]. Neurosci Res, 2008, 61: S28-S28.[131] Luc J Gentet, Michael Avermann, Feranc Matyas, et al. Membrane potential dynamics of GABAergic neurons in the barrel cortex of behaving mice [J]. Neuron, 2010, 65(3): 422-435.[132] Wei Wei, Justin Elstrott, Marla B Feller. Two-photon targeted recording of GFP-expressing neurons for light responses and live-cell imaging in the mouse retina [J]. Nat Protoc, 2010, 5(7): 1347-1352.[133] Davi D Bock, Wei-chung Allen Lee, Aaron M Kerlin, et al. Network anatomy and in vivo physiology of visual cortical neurons [J]. Nature, 2011, 471(7337): 177-182.[134] Ho Ko, Sonja B Hofer, Bruno Pichler, et al. Functional specificity of local synaptic connections in neocortical networks [J]. Nature, 2011, 473(7345): 87-91.[135] James A Fitzpatrick, Susan K Andreko, Lauren A Ernst, et al. Long-term persistence and spectral blue shifting of quantum dots in vivo [J]. Nano Lett, 2009, 9(7): 2736-2741.[136] Debasish Sen, Thomas J Deerinck, Mark H Ellisman, et al. Quantum dots for tracking dendritic cells and priming an immune response in vitro and in vivo [J]. PLoS One, 2008, 3(9): e3290.[137] Kurt F Ahrens, Barbara Heider, Hanson Lee, et al. Two-photon scanning microscopy of in vivo sensory responses of cortical neurons genetically encoded with a fluorescent voltage sensor in rat [J]. Front Neural Circuits, 2012, doi: 10.3389/fncir.2012.00015.[138] Ryota Homma, Bradley J Baker, Lei Jin, et al. Wide-field and two-photon imaging of brain activity with voltage- and calcium-sensitive dyes [J]. Philos Trans R Soc Lond B Biol Sci, 2009, 364(1529): 2453-2467.[139] Kuhn B, Denk W, Bruno R M. In vivo two-photon voltage-sensitive dye imaging reveals top-down control of cortical layers 1 and 2 during wakefulness [J]. Proc Natl Acad Sci USA, 2008, 105(21): 7588-7593.[140] Anna Letizia Allegra Mascaro, Leonardo Sacconi, Francesco S Pavone. Multi-photon nanosurgery in live brain [J]. Front Neuroenergetics, 2010, 2: 21.[141] Zuo Yi, Yang Guang, Kwon Elaine, et al. Long-term sensory deprivation prevents dendritic spine loss in primary somatosensory cortex [J]. Nature, 2005, 436(7048): 261-265.[142] Daniela Tropea, Ania K Majewska, Rodrigo Garcia, et al. Structural dynamics of synapses in vivo correlate with functional changes during experience-dependent plasticity in visual cortex [J]. J Neurosci, 2010, 30(33): 11086-11095.[143] Conor Liston, Wen-biao Gan. Glucocorticoids are critical regulators of dendritic spine development and plasticity in vivo [J]. Proc Natl Acad Sci USA, 2011, 108(38): 16074-16079.[144] Grace E Stutzmann, Ian Parker. Dynamic multiphoton imaging: a live view from cells to systems [J]. Physiology (Bethesda), 2005, 20: 15-21. [145] Yuji Ikegaya. Large-scale recordings for drug screening in neural circuit systems [J]. Yakugaku Zasshi, 2008, 128(9): 1251-1257.[146] Naoya Takahashi, Yuji Takahara, Daisuke Ishikawa, et al. Functional multineuron calcium imaging for systems pharmacology [J]. Anal Bioanal Chem, 2010, 398(1): 211-218.[147] Christie R H, Bacskai B J, Zipfel W R, et al. Growth arrest of individual senile plaques in a model of Alzheimer's disease observed by in vivo multiphoton microscopy [J]. J Neurosci, 2001, 21(3): 858-864.[148] Christie R, Kimchi E, Kajdasz S, et al. Multiphoton microscopy and amyloid angiopathy [J]. Amyloid, 2001, 8 (Suppl 1): 48-50.[149] Brian J Bacskai, William E Klunk, Chester A Mathis, et al. Imaging amyloid-beta deposits in vivo [J]. J Cereb Blood Flow Metab, 2002, 22(9): 1035-1041.[150] Klunk W E, Bacskai B J, Mathis C A, et al. Imaging Abeta plaques in living transgenic mice with multiphoton microscopy and methoxy-X04, a systemically administered Congo red derivative [J]. J Neuropathol Exp Neurol, 2002, 61(9): 797-805.[151] Gerhard Eichhoff, Olga Garaschuk. Two-photon imaging of neural networks in a mouse model of Alzheimer's disease [J]. Cold Spring Harb Protoc, 2011, 2011(10): 1206-1216.[152] Jaime Grutzendler, Gan Wen-biao. Two-photon imaging of synaptic plasticity and pathology in the living mouse brain [J]. NeuroRx, 2006, 3(4): 489-496.[153] Christian K E Jung, Martin Fuhrmann, Kamran Honarnejad, et al. Role of presenilin 1 in structural plasticity of cortical dendritic spines in vivo [J]. J Neurochem, 2011, 119(5): 1064-1073.[154] Tobias Bittner, Martin Fuhrmann, Steffen Burgold, et al. Multiple events lead to dendritic spine loss in triple transgenic Alzheimer's disease mice [J]. PLoS One, 2010, 5(11): e15477.[155] Marc Aurel Busche, Gerhard Eichhoff, Helmuth Adelsberger, et al. Clusters of hyperactive neurons near amyloid plaques in a mouse model of Alzheimer's disease [J]. Science, 2008, 321(5896): 1686-1689.[156] Kishore V Kuchibhotla, Carli R Lattarulo, Bradley T Hyman, et al. Synchronous hyperactivity and intercellular calcium waves in astrocytes in Alzheimer mice [J]. Science, 2009, 323(5918): 1211-1215.[157] Tristan Bolmont, Florent Haiss, Daniel Eicke, et al. Dynamics of the microglial/amyloid interaction indicate a role in plaque maintenance [J]. J Neurosci, 2008, 28(16): 4283-4292.[158] Liu Zhi-qiang, Carlo Condello, Aaron Schain, et al. CX3CR1 in microglia regulates brain amyloid deposition through selective protofibrillar amyloid-beta phagocytosis [J]. J Neurosci, 2010, 30(50): 17091-17101.[159] Payam Dibaj, Heinz Steffens, Jana Zschuntzsch, et al. In vivo imaging reveals rapid morphological reactions of astrocytes towards focal lesions in an ALS mouse model [J]. Neurosci Lett, 2011, 497(2): 148-151.[160] Payam Dibaj, Heinz Steffens, Jana Zschuntzsch, et al. In vivo imaging reveals distinct inflammatory activity of CNS microglia versus PNS macrophages in a mouse model for ALS [J]. PLoS One, 2011, 6(3): e17910.[161] Albrecht Sigler, Timothy H Murphy. In vivo 2-photon imaging of fine structure in the rodent brain: before, during, and after stroke [J]. Stroke, 2010, 41(10 Suppl): S117-123.[162] Timothy H Murphy, Li Ping, Betts Kellen, et al. Two-photon imaging of stroke onset in vivo reveals that NMDA-receptor independent ischemic depolarization is the major cause of rapid reversible damage to dendrites and spines [J]. J Neurosci, 2008, 28(7): 1756-1772.[163] Zhang Sheng-xiang, Jamie Boyd, Kerry Delaney, et al. Rapid reversible changes in dendritic spine structure in vivo gated by the degree of ischemia [J]. J Neurosci, 2005, 25(22): 5333-5338.[164] Zhang Sheng-xiang, Timothy H Murphy. Imaging the impact of cortical microcirculation on synaptic structure and sensory-evoked hemodynamic responses in vivo [J]. PLoS Biol, 2007, 5(5): e119.[165] Craig E Brown, Jamie D Boyd, Timothy H Murphy. Longitudinal in vivo imaging reveals balanced and branch-specific remodeling of mature cortical pyramidal dendritic arbors after stroke [J]. J Cereb Blood Flow Metab, 2010, 30(4): 783-791.[166] Ricardo Mostany, Tara G Chowdhury, David G Johnston, et al. Local hemodynamics dictate long-term dendritic plasticity in peri-infarct cortex [J]. J Neurosci, 2010, 30(42): 14116-14126.[167] Ricardo Mostany, Carlos Portera-Cailliau. Absence of large-scale dendritic plasticity of layer 5 pyramidal neurons in peri-infarct cortex [J]. J Neurosci, 2011, 31(5): 1734-1738.[168] Ding Shing-hua, Tommaso Fellin, Zhu Ying-zi, et al. Enhanced astrocytic Ca2+ signals contribute to neuronal excitotoxicity after status epilepticus [J]. J Neurosci, 2007, 27(40): 10674-10684.[169] Andy Y Shih, Beth Friedman, Patrick J Drew, et al. Active dilation of penetrating arterioles restores red blood cell flux to penumbral neocortex after focal stroke [J]. J Cereb Blood Flow Metab, 2009, 29(4): 738-751.[170] Hee-Pyoung Park, Anitha Nimmagadda, Richard A DeFazio, et al. Albumin therapy augments the effect of thrombolysis on local vascular dynamics in a rat model of arteriolar thrombosis: a two-photon laser-scanning microscopy study [J]. Stroke, 2008, 39(5): 1556-1562.[171] Nicholas Rensing, Yannan Ouyang, Yang Xiao-feng, et al. In vivo imaging of dendritic spines during electrographic seizures [J]. Ann Neurol, 2005, 58(6): 888-898.[172] Zeng Ling-hui, Xu Lin, Nicholas R Rensing, et al. Kainate seizures cause acute dendritic injury and actin depolymerization in vivo [J]. J Neurosci, 2007, 27(43): 11604-11613.[173] Tian Guo-feng, Hooman Azmi, Takahiro Takano, et al. An astrocytic basis of epilepsy [J]. Nat Med, 2005, 11(9): 973-981.[174] D Sesath Hewapathirane, Kurt Haas. Single cell electroporation in vivo within the intact developing brain [J]. J Vis Exp, 2008, doi 10.3791/705. [175] Sun Kwang Kim, Kei Eto, Junichi Nabekura. Synaptic structure and function in the mouse somatosensory cortex during chronic pain: in vivo two-photon imaging [J]. Neural Plast, 2012, 2012: 640259.[176] Sun Kwang Kim, Junichi Nabekura. Rapid synaptic remodeling in the adult somatosensory cortex following peripheral nerve injury and its association with neuropathic pain [J]. J Neurosci, 2011, 31(14): 5477-5482.[177] Kei Eto, Hiroaki Wake, Miho Watanabe, et al. Inter-regional contribution of enhanced activity of the primary somatosensory cortex to the anterior cingulate cortex accelerates chronic pain behavior [J]. J Neurosci, 2011, 31(21): 7631-7636.[178] Dimitrios Davalos, Jaime Grutzendler, Guang Yang, et al. ATP mediates rapid microglial response to local brain injury in vivo [J]. Nat Neurosci, 2005, 8(6): 752-758.[179] Thomas H Chia, Michael J Levene. Microprisms for in vivo multi-layer cortical imaging [J]. J Neurophysiol, 2009, 102(2): 1310-1314.[180] Demirhan Kobat, Nicholas G Horton, Chris Xu. In vivo two-photon microscopy to 1.6-mm depth in mouse cortex [J]. J Biomed Opt, 2011, 16(10): 106014.[181] Benjamin F Grewe, Dominik Langer, Hansjrg Kasper, et al. High-speed in vivo calcium imaging reveals neuronal network activity with near-millisecond precision [J]. Nat Methods, 2010, 7(5):399-405.[182] Brendon O Watson, Volodymyr Nikolenko, Rafael Yuste. Two-photon imaging with diffractive optical elements [J]. Front Neural Circuits, 2009, 3: 6.[183] Shigehiro Namiki, Norio Matsuki, Ikegaya Yuji. Large-scale imaging of brain network activity from >10,000 neocortical cells [J]. Nature Precedings, 2009, hdl:10101/npre.2009.2893.1.[184] Gergely Katona, Gergely Szalay, Pal Maak, et al. Fast two-photon in vivo imaging with three-dimensional random-access scanning in large tissue volumes [J]. Nat Methods, 2012, 9(2): 201-208.[185] Werner Gobel, Bjorn M Kampa, Fritjof Helmchen. Imaging cellular network dynamics in three dimensions using fast 3D laser scanning [J]. Nat Methods, 2007, 4(1): 73-79.[186] David S Greenberg, Arthur R Houweling, Jason N Kerr. Population imaging of ongoing neuronal activity in the visual cortex of awake rats [J]. Nat Neurosci, 2008, 11(7): 749-751.[187] James T Russell. Imaging calcium signals in vivo: a powerful tool in physiology and pharmacology [J]. Br J Pharmacol, 2011, 163(8): 1605-1625.[188] Henry Lutcke, Masanori Murayama, Thomas Hahn, et al. Optical recording of neuronal activity with a genetically-encoded calcium indicator in anesthetized and freely moving mice [J]. Front Neural Circuits, 2010, 4: 9. [189] Benjamin F Grewe, Fritjof Helmchen. Optical probing of neuronal ensemble activity [J]. Curr Opin Neurobiol, 2009, 19(5): 520-529. |
| No related articles found! |
| Viewed | ||||||
|
Full text |
|
|||||
|
Abstract |
|
|||||
