ACTA NEUROPHARMACOLOGICA ›› 2011, Vol. 1 ›› Issue (2): 42-47.

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Roles of Adenomatous Polyosis Coli in the Early Developing Cerebral Cortex

ZUO Wei, JI Hui,WANG Wen   

  1. 1. Xuanwu Hospital of Capital Medical University, Beijing, 100053, China
    2. China Pharmaceutical University, Nanjing, 210009, China
  • Online:2011-04-26 Published:2012-04-20

Abstract: Adenomatous polyosis coli(APC)is a large multifunctional protein known to be important for Wntβ-catenin signalling, cytoskeletal dynamics, and cell polarity. In the developing cerebral cortex, APC is expressed in proliferating cells and its expression increases as cells migrate to the cortical plate. In this article, we summarized the roles of APC in the early developing cerebral cortex. APC is required for multiple aspects of early cerebral cortical development, including the regulation of cell number, interkinetic nuclear migration, cell polarity, and cell type specification.

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