ACTA NEUROPHARMACOLOGICA

ACTA NEUROPHARMACOLOGICA ›› 2025, Vol. 15 ›› Issue (1): 43-.DOI: 10.3969/j.issn.2095-1396.2025.01.007

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Progress in Pharmacological Effects of Glycyrrhizic Acid and Its Application as Drug Carrier

ZHENG Hai-xin, LI Ting, YIN Hong-yan, ZHANG Hai-hong, WANG Shu   

  1. Department of Pharmacy, Hebei North University, Hebei Key Laboratory of Neuropharmacology, Zhangjiakou, 075000, China
  • Online:2025-02-26 Published:2025-06-20

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Abstract:

Glycyrrhiza uralensis Fisch is a traditional Chinese medicine with the functions of tonifying spleen and replenishing qi, expelling phlegm and relieving cough, clearing heat and detoxifying, and harmonizing other medicines. Its main active ingredient is Glycyrrhizic acid (GA), which is a triterpenoid saponin compound with antiviral, anti-tumor, anti-inflammatory, liver protection and various pharmacological activities. Glycyrrhizic acid has amphiphilic structure, which can spontaneously form micelles with core-shell structure. GA has the properties similar to surfactants and has good biological stability and solubility. With the progress of nanotechnology, it has become a research hotspot to modify glycyrrhizic acid with nanomaterials or self-assemble it into nanoparticles for the transport of various drugs to overcome the defects of low bioavailability and poor water solubility of drugs. This paper reviews the pharmacological activity and mechanism of glycyrrhizic acid and its application as a multifunctional drug carrier material, so as to provide reference for its further development, utilization and clinical research.

Key words: glycyrrhizic acid, pharmacological activity, self-assembly

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