ACTA NEUROPHARMACOLOGICA ›› 2020, Vol. 10 ›› Issue (1): 54-64.DOI: 10.3969/j.issn.2095-1396.2020.01.011

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Pathogenesis of Diluted Hyponatremia and Therapeutic Strategy

WANG Shu-yuan,YANG Bao-xue   

  1. State Key Laboratory of Natural and Biomimetic Drugs & Department of Pharmacology,School of Basic Medical Sciences,Peking University,Beijing,100191,China
  • Online:2020-02-26 Published:2020-02-26
  • Contact: 杨宝学,男,博士生导师,中国药理学会常务理事、肾脏药理学专业委员会主委;Tel:+86-010-82825622,E-mail:baoxue@bjmu.edu.cn
  • About author:王淑园,女,博士研究生;研究方向:药理学;Tel:+86-010-82805559,E-mail:shuyuan0127@outlook.com
  • Supported by:
    国家自然科学基金重点国际合作研究项目(No.81620108029);国家自然科学基金重点项目(No.81330074);国家自然科学基金面上项目(No.81974083)

Abstract:

Hyponatremia is the most common electrolyte disturbance encountered in clinical practice,occurring in approximately 15%~30% of hospitalized patients. Hyponatremia carries a poor prognosis,being associated with significant mortality and morbidity. This review aims to be insight into diluted hyponatremia,lay theoretical foundation for the treatment,and provide supports for the discovery of new types of diuretics by sorting out and discussing the pathogenesis and management of diluted hyponatremia in cirrhosis,syndrome of inappropriate antidiuretic hormone secretion and heart failure.

Key words: diluted hyponatremia, cirrhosis, syndrome of inappropriate antidiuretic hormone secretion, heart failure, diuretics