Acta Neuropharmacologica ›› 2016, Vol. 6 ›› Issue (2): 37-45.DOI: 10.3969/j.issn.2095-1396.2016.02.007

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Research Progress of Peony Main Active Monomers on Cerebral Ischemia

FENG Xiao-ye,SONG Xiu-yun,CHEN Nai-hong   

  1. 1. Chinese Academy of Medical Science and Peking Union Medical College,Beijing,100050,China
    2. School of Pharmacy,Hunan University of Chinese Medicine,Changsha,410208,China
  • Online:2016-04-26 Published:2016-05-10
  • Contact: 陈乃宏,男,研究员,博士生导师;研究方向:神经药理学和神经分子生物学;Tel:+86-010-63165177,Fax:+86-010-63165211,E-mail:chennh@imm.ac.cn
  • About author:冯小叶,女,学士;E-mail:649201711@qq.com
  • Supported by:

    国家自然科学基金项目(No.81274122、No.81373997、No.U1402221),国家“重大新药创制”科技重大专项(No.2012ZX09301002),新药作用机制研究与药效评价北京市重点实验室资助项目(No.BZ0150)

Abstract: Cerebral ischemic stroke which has characteristics of high morbidity,high mortality and high disability,is a kind of common diseases that threaten human health. It’s the precious wealth which is accumulated by ancient Chinese to treat cerebral ischemia with traditional Chinese medicine. The peony belongs to Paeonia L. of Ranunculaceae. The main active parts of peony are the root bark and seeds,especially the root bark. According to the theory of Chinese medicine,the root bark of peony is a kind of efficient drugs in promoting blood circulation and removing blood stasis. What’s more,modern pharmacological studies find that a variety of peony extract monomers have marked effects on improving cerebral ischemia stroke,which suggest that these monomers may be the potential drugs to treat ischemic cerebrovascular disease. And these peony extract monomers have the value of deep research and clinical application. Therefore,this paper reviewed the research progress of the main active monomers of peony on the effects of anti-cerebral ischemia stroke in recent years.

Key words: peony, cerebral ischemic stroke, pharmacology

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