Abstract: Cerebral ischemic stroke which has characteristics of high morbidity，high mortality and high disability，is a kind of common diseases that threaten human health. It’s the precious wealth which is accumulated by ancient Chinese to treat cerebral ischemia with traditional Chinese medicine. The peony belongs to Paeonia L. of Ranunculaceae. The main active parts of peony are the root bark and seeds，especially the root bark. According to the theory of Chinese medicine，the root bark of peony is a kind of efficient drugs in promoting blood circulation and removing blood stasis. What’s more，modern pharmacological studies find that a variety of peony extract monomers have marked effects on improving cerebral ischemia stroke，which suggest that these monomers may be the potential drugs to treat ischemic cerebrovascular disease. And these peony extract monomers have the value of deep research and clinical application. Therefore，this paper reviewed the research progress of the main active monomers of peony on the effects of anti-cerebral ischemia stroke in recent years.

Key words: peony, cerebral ischemic stroke, pharmacology