神经药理学报

神经药理学报 ›› 2025, Vol. 15 ›› Issue (2): 61-.DOI: 10.3969/j.issn.2095-1396.2025.02.011

• 综述 • 上一篇    

8-OHdG、G SH-PX 在脑小血管病所致血管性认知障碍中的研究进展

王天珉，薛茜，张雷，姜松   

  1. 1. 河北北方学院研究生学院，张家口，075000，中国 

    2. 河北北方学院附属第一医院神经内科，张家口，075000，中国

  • 出版日期:2025-04-25 发布日期:2025-08-25
  • 通讯作者: 薛茜，主任医师，教授，硕士生导师；研究方向：神经内科疾病；E-mail：xueqian6166@163.com
  • 作者简介:王天珉，河北北方学院 2023级硕士研究生；研究方向：神经病学；E-mail：849260746@qq.com

Research Progress of 8-OHdG and GSH-PX in Vascular Cognitive Impairment Caused by Cerebral Small Vessel Disease

WANG Tian-min, XUE Qian, ZHANG Lei, JIANG Song   

  1. 1. Graduate School of Hebei North University, Zhangjiakou, 075000, China 

    2. Department of Neurology, The First Affiliated Hospital of Hebei North University, Zhangjiakou, 075000, China

  • Online:2025-04-25 Published:2025-08-25

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摘要：

脑小血管病（cerebral small vessel disease, CSVD）是导致血管性认知障碍（vascular cognitive impairment, VCI）的主要病因之一。近年来，大量研究表明，氧化应激在CSVD 的发病机制中起着重要作用，其 中8- 羟基脱氧鸟苷（8-hydroxydeoxyguanosine，8-OHdG）作为氧化DNA 损伤的标志物和谷胱甘肽过氧化物酶 （glutathione peroxidase, GSH-PX）作为体内重要的抗氧化酶，其水平变化与脑血管病理及认知功能下降密切相 关。该文系统回顾了国内外关于8-OHdG 与GSH-PX 在CSVD 及VCI 中的研究进展，总结了两者在疾病早期 诊断、病情评估以及干预中的潜在应用价值，同时对存在的不足及未来研究方向进行了探讨。

关键词: 8-OHdG, GSH-PX, 脑小血管病, 血管性认知障碍, 氧化应激, 抗氧化

Abstract:

Cerebral small vessel disease (CSVD) is one of the main causes of Vascular cognitive impairment (VCI). In recent years, a large number of studies have shown that oxidative stress plays an important role in the pathogenesis of CSVD. Among them, 8-hydroxydeoxyguanosine (8-OHdG), as a marker of oxidative DNA damage, and Glutathione peroxidase (GSH-PX), as an important antioxidant enzyme in the body, the changes in their levels are closely related to cerebrovascular pathology and cognitive function decline. This article systematically reviews the research progress at home and abroad on 8-OHdG and GSH-PX in CSVD and VCI, summarizes the potential application values of the two in the early diagnosis, disease assessment, and intervention of the diseases, and at the same time discusses the existing deficiencies and future research directions.

Key words: 8-OHdG, GSH-PX, cerebral small vessel disease, vascular cognitive impairment, oxidative stress, antioxidant

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