神经药理学报 ›› 2020, Vol. 10 ›› Issue (2): 24-32.DOI: 10.3969/j.issn.2095-1396.2020.02.006

• 专题论著 • 上一篇    下一篇

L- 茶氨酸药理作用的研究进展

刘杉,李炜   

  1. 1. 河北北方学院药学系,河北省神经药理学重点实验室,张家口,075000,中国
    2. 北京托毕西药业有限公司,北京,100036,中国
  • 出版日期:2020-04-26 发布日期:2020-04-26
  • 通讯作者: 李炜,女,硕士,硕士生导师;研究方向:神经药理学;E-mail:leewei318@163.com
  • 作者简介:刘杉,女,药学学士
  • 基金资助:
    河北北方学院面上项目(No.12995363)

Research Progress on Pharmacological Effects of L-theanine

LIU Shan,LI Wei   

  1. 1.  Department of Pharmacy,Hebei North University,Hebei Key Laboratory of Neuropharmacology,Zhangjiakou,075000,China
    2. Beijing Tuobixi Pharmaceutical Co. LTD,Beijing,100036,China
  • Online:2020-04-26 Published:2020-04-26
  • Contact: 李炜,女,硕士,硕士生导师;研究方向:神经药理学;E-mail:leewei318@163.com
  • About author:刘杉,女,药学学士
  • Supported by:
    河北北方学院面上项目(No.12995363)

摘要:

L- 茶氨酸(L-The)是绿茶中提取出的一种非蛋白质类氨基酸,抗氧化作用极强,具有多种药理作用。对于中枢神经系统,L-The 可以通过直接地促进神经因子的发生和间接地抗氧化等保护作用,改善认知功能,有利于阿尔茨海默症(Alzheimer’s disease,AD)的治疗;通过发挥抗氧化、抗炎的特性起到神经保护剂的作用;通过升高α波活性、上调多巴胺水平,起到改善情绪和睡眠的作用。对于心血管系统,L-The 可通过调节NO 水平、调节昼夜紊乱、降低低密度脂蛋白(low density lipoprotein,LDL)水平来预防心血管疾病。对于肿瘤治疗,L-The可通过促进肿瘤细胞凋亡、调节抗癌药的体内分布水平起到抗癌的辅助作用;还能通过抗氧化作用对多个器官起到保护作用,包括治疗过程中降低药物对机体的损伤。对于免疫系统,L-The 能提高脾脏的重量,提高免疫力,降低病毒感染风险。对于机体代谢,L-The 在人体中能促进葡萄糖代谢,降低Ⅱ型糖尿病发生风险;还能促进运动后体力恢复。L-The 广泛的药理作用使其研究前景十分广阔,得到了国内外学者的高度重视。该文以当前L-The 在药理学相关领域的研究为基础,对L-The 在中枢神经系统、心血管系统、抗肿瘤、降低毒性、免疫系统以及代谢调节这六个方面的药理作用进行了综述,以期为L-The 的研发和临床用药研究提供理论参考。

关键词: L- 茶氨酸, 抗氧化, 神经保护, 抗肿瘤, 增强免疫

Abstract:

L-theanine (L-The) is a non-protein amino acid extracted from green tea. It has strong antioxidant activity and various pharmacological effects. For the central nervous system,L-The can improve cognitive function by directly promoting the occurrence of neurokines and indirectly resisting oxidation and other protective effects,which is beneficial to the treatment of AD. Besides,L-The,by exerting the characteristics of anti-oxidation and anti-inflammation,plays a role in neuroprotective agents. What`s more,it can also improve mood and sleep by increasing the activity of α wave and up-regulating the level of dopamine. For cardiovascular system,L-The can prevent cardiovascular disease by regulating NO level,regulating diurnal disorder and reducing LDL level. For tumor treatment,L-The can play an auxiliary role in anti-cancer by promoting tumor cell apoptosis and regulating the biological distribution of anticancer drugs;it can also protect multiple organs through anti-oxidation,including reducing drug damage to the body during treatment. For the immune system,L-The can increase the weight of the spleen,improve immunity,and reduce the risk of viral infection. For metabolism,L-The can also promote glucose metabolism and reduce the risk of type Ⅱ diabetes,and promote physical recovery after exercise. Because of its extensive pharmacological effects,L-The has a broad research prospect,which has been highly valued by scholars at home and abroad,and the related research is also gradually increasing. Based on the current research on pharmacology of L-The, the pharmacological effects of L-The on central nervous system,cardiovascular system,antitumor, reducing toxicity,immune system and metabolic regulation were reviewed. It is hoped that it can provide theoretical reference for the research and development of L-the and clinical medication.

Key words: L-theanine(L-The), antioxidant, neuroprotection, anti-tumor, strengthen the , immune