神经药理学报

神经药理学报 ›› 2024, Vol. 14 ›› Issue (2): 54-.DOI: 10.3969/j.issn.2095-1396.2024.02.009

• 综述 • 上一篇    下一篇

姜黄素纳米制剂研究进展

袁鑫茹，张丹参   

  1. 河北科技大学化学与制药工程学院，石家庄，050018，中国
  • 出版日期:2024-04-26 发布日期:2024-07-11
  • 通讯作者: 张丹参，博士生导师；研究方向：神经药理学； Tel： +86-0311-81668016， E-mail： zhangds2011@126.com
  • 作者简介:袁鑫茹，硕士研究生；研究方向：神经药理学； E-mail： yuanxr111@126.com
  • 基金资助:
    河北省重点研发计划项目生物医药专项（No.20372509D）；河北省自然科学基金项目（No.H2020208032）

Research Progress of Curcumin Nano-Preparations

YUAN Xin-ru，ZHANG Dan-shen   

  1. College of Chemistry and Pharmaceutical Engineering，Hebei University of Science and Technology，Shijiazhuang， 050018，China
  • Online:2024-04-26 Published:2024-07-11

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摘要：

姜黄素(curcumin, Cur)是从姜黄属类植物的根茎中提取出来的一种二酮类化合物，具有抗氧化、抗炎、 抗肿瘤、神经保护等广泛药理活性，但溶解度低、半衰期短、生物利用度低、难透过血脑屏障等缺点，限制了在临 床中的应用。近年来，将其制备成脂质体、固体分散体、聚合物纳米粒、聚合物胶束、纳米混悬剂等，明显改善了 Cur的溶解度和生物利用度及靶向性，提高药物活性。该文就Cur的纳米制剂进行综述，旨在为其进一步研究和 开发提供参考。

关键词: 姜黄素, 纳米制剂, 研究进展

Abstract:

Curcumin (Cur) is a diketone compound extracted from the rhizomes of the genus turmeric, which has a wide range of pharmacological activities such as antioxidant, anti-inflammatory, anti-tumor, and neuroprotection, but has low solubility, short half-life, low bioavailability, difficult to penetrate the blood-brain barrier and other shortcomings limit its clinical application. In recent years, it has been prepared into liposomes, solid dispersions, polymer nanoparticles, polymer micelles, nanosuspensions, etc., which significantly improved the solubility, bioavailability and targeting of Cur, and improved drug activity. This article reviewed the nano-preparations of Cur, aiming to provide references for its further research and development.

Key words: curcumin, nano-preparation, research progress

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