神经药理学报 ›› 2024, Vol. 14 ›› Issue (2): 47-.DOI: 10.3969/j.issn.2095-1396.2024.02.008

• 综述 • 上一篇    下一篇

TRIM32 与相关神经系统疾病的研究进展

孙晓静,孟宪勇,余会娇,董晓华   

  1. 1. 河北北方学院药学院,河北省神经药理学重点实验室,张家口,075000,中国 

    2. 河北北方学院附属第一医院,张家口,075000,中国

  • 出版日期:2024-04-26 发布日期:2024-07-11
  • 通讯作者: 董晓华,教授,博士,硕士研究生导师;研究方向:神经精神药理学;Tel:+86-0313-4029421,E-mail:hbdxh76@163.com
  • 作者简介:孙晓静,硕士研究生;研究方向:神经精神药理学;Tel:+86-0313-4029421,E-mail:2982586826@qq.com
  • 基金资助:
    河北省卫生厅资助项目(No.2016035)

Research Progress of TRIM32 and Related Nervous System Diseases

SUN Xiao-jing, MENG Xian-yong, YU Hui-jiao, DONG Xiao-hua   

  1. 1. Department of Pharmacy, Hebei North University, Hebei Key Laboratory of Neuropharmacology, Zhangjiakou, 075000, China 

    2. The First Affiliated Hospital of Hebei North University, Zhangjiakou, 075000, China

  • Online:2024-04-26 Published:2024-07-11

摘要:

三结构域蛋白家族(tripartite motif protein, TRIM)是一类被广泛涉及于生物学过程中的蛋白质,其功 能包含细胞生长、分化、发育、凋亡、免疫应答和肿瘤发生等方面。其中,TRIM32 是一种E3 泛素连接酶,隶属于 TRIM 蛋白家族。虽然关于TRIM32 的相关研究较少,但其在维持神经系统的生理功能方面作用极为重要。因此, 该文旨在综述TRIM32 在神经系统疾病中的作用。

关键词: TRIM32, 泛素连接酶, 神经系统疾病

Abstract:

Tripartite motif proteins (TRIM) are a class of proteins involved in a wide range of biological processes, including cell growth and differentiation, development, apoptosis, immune response, and tumorigenesis. Among them, TRIM32 is an E3 ubiquitin ligase that belongs to the TRIM protein family. Although there are few studies on TRIM32, its role in maintaining the physiological function of the nervous system is extremely important. Therefore, this review aims to review the role of TRIM32 in neurological diseases.

Key words: TRIM32, ubiquitin ligase enzyme, nervous system disease

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