神经药理学报

神经药理学报 ›› 2024, Vol. 14 ›› Issue (2): 38-.DOI: 10.3969/j.issn.2095-1396.2024.02.007

• 研究论文 • 上一篇    下一篇

食管胃交界腺癌和远端胃腺癌中 HER2、RKIP 及ERK 表达的对比研究

付雨桐，李慧敏，董心怡，杜世璇，娄蕾，崔晋峰，王娟，张庆，苏凌瑞，李月红   

  1. 1. 河北医科大学第二医院，石家庄，050000，中国 

    2. 石家庄市第三医院，石家庄，050000，中国 

    3. 河北医科大学第四医院，石家庄，050000，中国

  • 出版日期:2024-04-26 发布日期:2024-07-11
  • 通讯作者: 李月红，博士研究生，主任医师；研究方向：肿瘤病理
  • 作者简介:付雨桐，硕士研究生；研究方向：肿瘤病理；E-mail：fuu1996@163.com
  • 基金资助:
    河北省医学科学研究重点课题计划项目（No：20170086），政府资助临床医学优秀人才项目（No：ZF2024036），中央引导地方科 技发展资金项目（No：236Z7747G），河北省医学适用技术跟踪项目（No：GZ2021045），河北医科大学第二医院科学研究基金项 目（No：2HC202128）

Comparative Stud y of HER 2, RKIP and ERK Ex pression in Adenocarcinoma of Es ophagogastric J unction and D istal Gastric Adenocarcinoma

FU Yu-tong，LI Hui-min，DONG Xin-yi，DU Shi-xuan，LOU Lei，CUI Jin-feng，WANG Juan，ZHANG Qing， SU Ling-rui，LI Yue-hong   

  1. 1. The Second Hospital of Hebei Medical University, Shijiazhuang, 050000, China 

    2. The Third Hospital of Shijiazhuang, Shijiazhuang, 050000, China 

    3. The Fourth Hospital of Hebei Medical University, Shijiazhuang, 050000, China

  • Online:2024-04-26 Published:2024-07-11

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摘要：

目的：比较HER2、RKIP 和ERK 在食管胃交界腺癌（adenocarcinoma of esophagogastric junction，AEG） 及远端胃腺癌（distal gastric adenocarcinoma，DGA）中的表达情况，并探讨AEG 与DGA 发病机制的差异。方 法：通过免疫组化法检测AEG、DGA 及正常胃黏膜组织中HER2、RKIP 及ERK 的表达情况，分析HER2、RKIP 及ERK 与临床病理学特征的关系及三者相关性。结果：AEG 中HER2 阳性表达率高于DGA，差异有统计学意 义(P<0.05)。AEG 及DGA 中RKIP 阳性表达率均低于正常胃黏膜组织，ERK 阳性表达率均高于正常胃黏膜组 织（P<0.05)。AEG 中，RKIP 在高/ 中分化、淋巴结转移组中阳性表达率较低，ERK 在低分化、浸润浆膜层、淋巴 结转移组中阳性表达率较高（P<0.05)；HER2 与ERK 表达正相关(r=0.352，P=0.007)，RKIP 与ERK 表达负相 关(r=-0.521，P=0.000)。DGA 中，RKIP 在低分化、淋巴结转移组中阳性表达率较低，ERK 在淋巴结转移组中阳 性表达率较高（P<0.05)；RKIP 与ERK 表达负相关(r=-0.287，P=0.021)。结论：AEG 中HER2 阳性表达率高于 DGA，ERK 高表达与AEG 患者临床病理特征的关系更为密切，RKIP 表达与AEG 和DGA 的分化程度和淋巴结 转移情况密切相关。HER2、RKIP、ERK 在AEG 与DGA 中的表达不同，提示不同部位胃腺癌的MAPK 信号通 路调节机制并不完全一致。

关键词: HER2, RKIP, ERK, 食管胃交界腺癌, 远端胃腺癌, 免疫组织化学

Abstract:

Objective: To compare the expression of HER2, RKIP, and ERK in adenocarcinoma of esophagogastric junction (AEG) and distal gastric adenocarcinoma(DGA), and explore the differences in the pathogenesis of AEG and DGA. Methods: The expression of HER2, RKIP and ERK in AEG, DGA and normal gastric mucosal tissue were detected by immunohistochemistry, and the relationship between HER2, RKIP, and ERK with clinical pathological characteristics and their correlation were analyzed. Results: The positive expression rate of HER2 in AEG was higher than that in DGA, and the difference was statistically significant (P<0.05). The positive expression rates of RKIP in AEG and DGA were lower than that in normal gastric mucosal tissue, while the positive expression rates of ERK were higher than that in normal gastric mucosal tissue (P<0.05). In AEG, the positive expression rate of RKIP was lower in the high/moderate differentiation group and lymph node metastasis group, while the positive expression rate of ERK was higher in the low differentiation group, serosa invasion group, and lymph node metastasis group (P<0.05); HER2 expression was positively correlated with ERK expression (r=0.352, P=0.007), while RKIP expression was negatively correlated with ERK expression (r=-0.521, P=0.000).In DGA, the positive expression rate of RKIP was lower in the poorly differentiated group and lymph node metastatic group, while the positive expression rate of ERK was higher in the lymph node metastatic group (P<0.05); RKIP expression was negatively correlated with ERK expression (r=-0.287, P=0.021). Conclusion: The positive expression rate of HER2 in AEG is higher than that in DGA, and the high expression of ERK is more closely related to the clinicopathological characteristics of AEG patients. The expression of RKIP is closely related to the differentiation degree and lymph node metastasis of AEG and DGA. The expression of HER2, RKIP, and ERK in AEG and DGA is different, indicating that the regulatory mechanism of MAPK signaling pathway is not completely consistent in different locations of gastric adenocarcinoma.

Key words: HER2, RKIP, ERK, adenocarcinoma of esophagogastric junction, distal gastric adenocarcinoma, immunhistochemistry

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