神经药理学报

神经药理学报 ›› 2022, Vol. 12 ›› Issue (4): 49-57.DOI: 10.3969/j.issn.2095-1396.2022.04.005

• 综述 • 上一篇    下一篇

柴胡- 黄芩调控中枢神经系统功能研究进展

李晨阳，赵姣娇，张炜   

  1. 河北医科大学中西医结合研究所，石家庄，050017，中国
  • 出版日期:2022-08-26 发布日期:2023-08-30
  • 通讯作者: 张炜，河北医科大学教授，博士生导师；研究方向：中药神经药理；Tel：+86-311-86266222，E-mail：weizhang@hebmu.edu.cn
  • 作者简介:李晨阳，硕士研究生；研究方向：中药神经药理；E-mail：1563325842@qq.com 赵姣娇，硕士研究生；研究方向：中药神经药理；E-mail：851663967@qq.com
  • 基金资助:
    国家自然科学基金资助项目（No.81872848）

Research Progress in Regulation of Central Nervous System Function by Radix Bupleuri and Scutellaria Baicalensis

LI Chen-yang，ZHAO Jiao-jiao，ZHANG Wei   

  1. Institute of Integrated Traditional Chinese and Western Medicine，Hebei Medical University，Shijiazhuang，050017， China
  • Online:2022-08-26 Published:2023-08-30

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摘要：

柴胡与黄芩是古代方剂中常见的药对配伍，在很多著名古方中均有记载。现代药理研究表明柴胡- 黄 芩在防治癫痫、抑郁、阿尔茨海默症、脑胶质瘤、脑缺血再灌注等方面表现出良好的效果，其机制为通过调控神经 细胞信号通路、炎症因子水平、细胞凋亡过程、神经递质含量等机制发挥防治中枢神经系统疾病的作用，且两药 配伍对神经保护具有协同作用，该文综述了国内外学者对柴胡- 黄芩及其化学成分防治中枢神经系统疾病的相 关研究，旨在为更好地研究开发和合理利用两种药物提供参考。

关键词: 柴胡, 黄芩, 炎症, 凋亡, 信号通路, 中枢神经系统

Abstract:

The compatibility of Radix Bupleuri and Scutellaria Baicalensis was common in ancient prescriptions and was recorded in many famous ancient prescriptions. Modern pharmacological studies showed that the combination of Radix Bupleuri and Scutellaria Baicalensis had good effects on the prevention and treatment of epilepsy，depression， Alzheimer’s disease，glioma，and cerebral ischemia-reperfusion. The combination of the two drugs synergistically protected nerves and played a role in the prevention and treatment of central nervous system diseases by regulating nerve cell signaling pathways，inflammatory factor level，cell apoptosis process，neurotransmitter content，and other mechanisms. In this paper，the domestic and foreign research on the prevention and treatment of central nervous system diseases by Radix Bupleuri-Scutellaria baicalensis and its chemical components were reviewed，aiming to provide a reference for better research and development and rational utilization of the two drugs.

Key words: radix bupleuri, scutellaria baicalensis, inflammation, apoptosis, signal pathway, central nervous system