神经药理学报

神经药理学报 ›› 2025, Vol. 15 ›› Issue (6): 59-.DOI: 10.3969/j.issn.2095-1396.2025.06.008

• 综述 • 上一篇    

Sinomenine抗抑郁作用机制研究进展

刘心雨，王志坚，沈忠飞，郭燕君   

  1. 嘉兴大学医学院，嘉兴，314001，中国
  • 出版日期:2025-12-26 发布日期:2026-03-30
  • 通讯作者: 沈忠飞，教授；研究方向：抑郁症基础与临床；郭燕君，副教授；研究方向：神经炎症和免疫机制研究
  • 作者简介:刘心雨，研究方向：抑郁症基础与临床
  • 基金资助:
    浙江省基础公益研究计划项目(No.ZCLTGD24C0901)；嘉兴大学校级SRT 计划项目(No.8517241021)；2025 年嘉兴大学国家级大学生创新训练计划（No.202510354033）

Research Progress on Mechanism of Antidepressant Action of Sinomenine

LIU Xin-yu, WANG Zhi-jian, SHEN Zhong-fei, GUO Yan-jun   

  1. Jiaxing University School of Medicine, Jiaxing, 314001, China
  • Online:2025-12-26 Published:2026-03-30

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摘要：

抑郁症是一种复杂的精神系统疾病，常伴随情感调节异常及认知功能损伤，以高复发率、功能损害显著 及临床缓解困难为特征。针对传统抗抑郁药物存在的耐受性差及停药反应等问题，探索源于天然产物的新型治 疗策略具有重要临床价值。青藤碱（sinomenine，SIN）是从中药青风藤等植物中分离得到的苄基异喹啉类生物碱， 其独特的抗炎与免疫调节特性为抑郁障碍干预提供了新方向。近年来SIN 治疗抑郁症的研究较多，该文从神经 递质系统、神经炎症反应、神经营养因子、神经可塑性及表观遗传学调控方面对SIN 抗抑郁症的作用机制作一综 述，为SIN 的基础研究和新型抗抑郁药物开发提供理论依据，为临床应用提供参考。

关键词: sinomenine, 抑郁症, 神经炎症, 神经可塑性, HPA 轴, 表观遗传

Abstract:

Depression is a complex mental health disorder, often involving abnormal emotional regulation and cognitive impairments, marked by high recurrence rates, significant functional impairment, and challenges in achieving clinical remission. Exploring novel therapeutic strategies derived from natural products holds significant clinical value in tackling issues like poor tolerance and withdrawal symptoms linked to traditional antidepressants. Sinomenine (SIN) is a benzylisoquinoline alkaloid extracted from plants like Sinomenium acutum, and its unique anti-inflammatory and immuneregulating properties offer a new approach for treating depressive disorders. Recently, there's been a lot of research on using SIN to treat depression. This article looks at how SIN works as an antidepressant by examining neurotransmitter systems, neuroinflammatory responses, neurotrophic factors, neuroplasticity, and epigenetic regulation, offering a theoretical foundation for further research and the development of new antidepressant drugs, along with insights for clinical use.

Key words: sinomenine, depression, neuroinflammation, neuroplasticity, HPA axis, epigenetics

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