神经药理学报

神经药理学报 ›› 2021, Vol. 11 ›› Issue (5): 48-.DOI: 10.3969/j.issn.2095-1396.2021.05.008

• 专题论著 • 上一篇    下一篇

生命早期血压中枢敏化的机制和意义

修天元，彭伟   

  1. 1. 河北北方学院附属第二医院，张家口，075100，中国  2. 河北北方学院，张家口，075000，中国
  • 出版日期:2021-10-26 发布日期:2021-10-26
  • 通讯作者: 彭伟，教授，硕士生导师；研究方向：心血管内科及卫生事业管理
  • 作者简介:修天元，河北北方学院2018 级研究生；研究方向：心血管病；E-mail: terry_sue@163.com

Mechanism and Significance of Blood Pressure Central Sensitization in Early Life

XIU Tian-yuan，PENG Wei   

  1. 1 The Second Affiliated Hospital of Hebei North University，Zhangjiakou，0751000，China  2 Hebei North University，Zhangjiakou，0750000，China
  • Online:2021-10-26 Published:2021-10-26

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摘要：

高血压作为全球罹患人数第一的心脑血管疾病，人们对其认识已逐渐深入到中枢基团、炎性因子等微观调控领域。在同样的生活条件下，何种群体更易被诱发高血压、其诱发机制又如何，已成为高血压一级预防里最为重要的研究方向。母代孕期和哺乳期的高脂饮食，可上调子代中枢系统的血压相关核团的表达，使血压中枢敏感性增加，成年后更易形成代谢综合征的表观遗传，导致对比其他人群在暴露于交感兴奋的高危因素下，如高脂、高盐、高糖摄入等情况时，更易出现血压升高的不良反应，现综述生命早期血压中枢敏化的机制和意义。

关键词: 高脂饮食, 高血压, 血压中枢敏化, 表观遗传, 健康编程

Abstract:

Hypertension is one of the most common cardiovascular and cerebrovascular diseases in the world，and its understanding has gradually penetrated into the fields of centra and inflammatory factors. Under the same living conditions，which groups are more likely to induce hypertension and the mechanism of its induction have become the most important research direction in the primary prevention of hypertension. Generation of a high-fat diet during pregnancy and lactation，can raise the offspring of central nervous system related to blood pressure，increase high blood pressure，central sensitivity，adults are more likely to form the epigenetic metabolic syndrome，compared with other groups in exposure to the risk factors of sympathetic activation，such as high fat，high salt，high sugar intake，and so on and so forth，are more likely to appear blood pressure of adverse reactions. This article reviews the mechanism and significance of central sensitization of hypertension in early life.

Key words: high fat diet, hypertension, hypertension center sensitization, epigenetics, health program

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