神经药理学报

神经药理学报 ›› 2024, Vol. 14 ›› Issue (6): 50-.DOI: 10.3969/j.issn.2095-1396.2024.06.008

• 综述 • 上一篇    下一篇

GABAA 受体与中枢神经系统疾病研究进展

张冉冉，张春月，吴志刚   

  1. 河北北方学院药学院，张家口市中药防治神经退行性疾病重点实验室，河北省神经药理学重点 实验室，张家口，075000，中国
  • 出版日期:2024-12-26 发布日期:2024-12-26
  • 通讯作者: 吴志刚，硕士生导师；研究方向：神经药理学；E-mail：wuzhigang1982@126.com
  • 作者简介:张冉冉，硕士研究生；研究方向：神经药理学；E-mail：2280479391@qq.com
  • 基金资助:
    河北省研究生创新资助项目（No. CXZZSS2024129）；河北北方学院校级科研项目（No.XJ2023034）

Research Progress of GABAA Receptor and Central Nervous System Diseases

ZHANG Ran-ran, ZHANG Chun-yue, WU Zhi-gang   

  1. College of Pharmacy, Hebei North University, Zhangjiakou Key Laboratory of Traditional Chinese Medicine for the Prevention and Treatment of Neurodegenerative Diseases, Hebei Key Laboratory of Neuropharmacology, Zhangjiakou, 075000, China
  • Online:2024-12-26 Published:2024-12-26

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摘要：

GABAA 受体是由多种亚基组成的五聚体，亚基组成不仅决定GABAA 受体的细胞位置还影响它们的生 物功能。当亚基发生突变时，受体不能有效地响应突触前神经元和神经胶质释放的GABA，从而导致中枢神经系 统疾病产生。该文将围绕GABAA 受体与中枢神经系统常见疾病进行综述，力求为该类疾病的治疗提供理论依据。

关键词: GABAA 受体, 中枢神经系统疾病, 研究进展

Abstract:

GABAA receptors are pentamers composed of multiple subunits, which not only determine the cellular location of GABAA receptors but also affect their biological functions. When the subunit is mutated, the receptor cannot effectively respond to GABA released by presynaptic neurons and glia, resulting in central nervous system diseases. This article will review the relationship between GABAA receptor and common diseases of central nervous system, and strive to provide theoretical basis for the treatment of these diseases.

Key words: GABAA receptor, central nervous system diseases, research progress

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