神经药理学报 ›› 2020, Vol. 10 ›› Issue (4): 58-64.DOI: 10.3969/j.issn.2095-1396.2020.04.010

• 综述 • 上一篇    

病原微生物与阿尔茨海默病相关性研究进展

海吉涛,罗焕敏   

  1. 1 暨南大学基础医学院药理系,广州,510632,中国
    2 暨南大学脑科学研究所,广州,510632,中国
  • 出版日期:2020-08-26 发布日期:2020-08-26
  • 通讯作者: 罗焕敏,男,博士,教授,博士生导师;研究方向:神经药理学;E-mail:tlhm@jnu.edu.cn
  • 作者简介:海吉涛,男,硕士研究生;研究方向:神经药理学;E-mail:2458520104@qq.com

Progress on the Relationship between Pathogenic Microorganisms and Alzheimer’s Disease

HAI Ji-tao,LUO Huan-min   

  1. 1 Department of Pharmacy,School of Basic Medicine,Jinan University,Guangzhou,510632,China
    2 Institute of Brain Science,Jinan University,Guangzhou,510632,China
  • Online:2020-08-26 Published:2020-08-26
  • Contact: 罗焕敏,男,博士,教授,博士生导师;研究方向:神经药理学;E-mail:tlhm@jnu.edu.cn
  • About author:海吉涛,男,硕士研究生;研究方向:神经药理学;E-mail:2458520104@qq.com

摘要:

阿尔茨海默病(Alzheimer’s disease,AD)是导致老年痴呆的主要原因,也是一种影响老年人健康的脑疾病。迄今为止虽已有不少AD 的发病机制的理论被提出,但根据这些理论所开发的药物或治疗方法仍不能阻止该病的发展。最近的“感染假说”研究表明,多种病原微生物可以直接穿过血脑屏障,到达大脑,引起炎症反应,造成神经元损伤。最常见的病原微生物有肺炎衣原体、螺旋体、幽门螺旋杆菌、牙龈卟啉单胞菌、真菌、单纯疱疹病毒Ⅰ型及巨细胞病毒。在此我们主要讨论了病原微生物在AD 发生和发展中的潜在作用,充分阐述了病原体与AD 之间的联系,为AD 发病机制及其预防、治疗研究提供依据。

关键词: 阿尔茨海默病, 细菌, 病毒, 真菌, 炎症, 感染

Abstract:

Alzheimer’s disease( AD),a cerebral disease,accounts for the majority of senile dementia that affects the health of the old. Although many theories on AD pathogenesis have been proposed,so far,there are no effective treatments to restrict its development. Recently “infection hypothesis” of AD have shown that a variety of pathogenic microorganism can directly penetrate
the blood-brain barrier (BBB),reach the brain,cause inflammatory reactions,and damage neurons. The most common pathogens through BBB are herpes simplex virus,Cytomegalovirus,Chlamydia pneumoniae,Spirochetes,Helicobacter pylori,Porphyromonas gingivalis,Fungus. In this article,we mainly discussed the potential role of pathogenic microorganisms in the etiologyand progression of AD,expounded the relationship between pathogens and AD,which would provide theoretical basis for the pathogenesis,prevention and treatment of AD.

Key words: Alzheimer’s disease, bacteria, virus, fungi, inflammation, infection

中图分类号: