神经药理学报 ›› 2020, Vol. 10 ›› Issue (1): 40-46.DOI: 10.3969/j.issn.2095-1396.2020.01.009

• 综述 • 上一篇    下一篇

植物雌激素介导线粒体途径对阿尔茨海默病神经保护作用的研究进展

甄艳杰,郭童林,赵雨薇,沈丽霞   

  1. 河北北方学院药学系,张家口,075000,中国
  • 出版日期:2020-02-26 发布日期:2020-02-26
  • 通讯作者: 沈丽霞,女,博士,教授,硕士生导师;研究方向:神经药理学;Tel:+86-0313-4029305,E-mail:shenlixiacn@163.com
  • 作者简介:甄艳杰,女,硕士研究生;研究方向:神经药理学;E-mail:Zhenyj@163.com
  • 基金资助:
    河北省自然科学基金资助项目(No.H2019405057),河北省高等学校科学技术研究项目(No.ZD2020136)

Study Progress on Phytoestrogen-Mediated Mitochondrial Pathway’s Neuroprotective Effects in Alzheimer’s Disease

ZHEN Yan-jie,GUO Tong-lin,ZHAO Yu-wei,SHEN Li-xia   

  1. Department of Pharmacy,Hebei North University,Zhangjiakou,075000,China
  • Online:2020-02-26 Published:2020-02-26
  • Contact: 沈丽霞,女,博士,教授,硕士生导师;研究方向:神经药理学;Tel:+86-0313-4029305,E-mail:shenlixiacn@163.com
  • About author:甄艳杰,女,硕士研究生;研究方向:神经药理学;E-mail:Zhenyj@163.com
  • Supported by:
    河北省自然科学基金资助项目(No.H2019405057),河北省高等学校科学技术研究项目(No.ZD2020136)

摘要:

阿尔茨海默病(Alzheimer’s disease,AD)是一种多发于老年人的神经退行性疾病,主要表现为记忆减退、认知功能障碍和行为异常等。研究发现雌激素(estrogen,ER)替代治疗可以延缓AD 病情进展,但是其应用又会导致各种副作用,因此寻找新的治疗方法成为必然趋势。研究显示与17β- 雌二醇结构相似的植物雌激素(phytoestrogen,PE)对于治疗AD 有较好疗效且副作用较少,能够代替雌激素在治疗AD 上发挥神经保护作用。众所周知,线粒体是所有细胞形态的细胞存活的重要因素,神经元正常功能的运行在很大程度上依赖于线粒体的健康情况。而该文将就植物雌激素介导线粒体途径发挥对神经元的保护作用的相关内容做一综述。

关键词: 阿尔茨海默病, 植物雌激素, 线粒体, 神经保护作用

Abstract:

Alzheimer’s disease (AD) is a neurodegenerative disease that is more common in the elderly,mainly manifesting as memory loss,cognitive dysfunction,and behavioral abnormalities. Studies have found that estrogen (ER) replacement therapy can delay the progression of AD,but its application can cause various side effects,so finding new treatments has become an inevitable trend. Studies have shown phytoestrogen (PE),which has a similar structure to 17β-estradiol,has a good effects on AD and has fewer side effects,and can replace estrogen to play a neuroprotective role in treating AD. It is well known that mitochondria are an important factor for cell survival in all cell morphologies. The normal functioning of neurons depends to a large extent on the health of mitochondria. This text will review the related content of the phytoestrogens-mediated mitochondrial protective effect on neurons.

Key words: Alzheimer’s disease, phytoestrogens, mitochondria, neuroprotective effects