右美托咪定应用于围术期镇痛的研究进展

doi:10.3969/j.issn.2095-1396.2019.06.009

摘要/Abstract

摘要：

右美托咪定作为一种高选择性α2 肾上腺素能受体激动剂，具有镇静、镇痛和减轻应激反应等作用。大量的研究证实，围术期应用右美托咪定，不但具有辅助镇痛作用，还可减少其他镇痛药物的用量，减轻其不良反应，增强其镇痛效果，从而提高患者围术期的舒适度，保持血流动力学稳定，减少术后疼痛反应。该文就右美托咪定应用于围术期镇痛的研究进展进行综合阐述。

关键词: 右美托咪定, 围术期, 镇痛

Abstract:

Dexmedetomidine，as a highly selective 2 adrenergic receptor agonist，has sedative，analgesic and stress-relieving effects. A large number of studies have confirmed that the perioperative application of dexmedetomidine not only has an auxiliary analgesic effect， but also can reduce the dosage of other analgesic drugs，reduce its adverse reactions，and enhance its analgesic effect，so as to improve the perioperative comfort of patients，maintain hemodynamic stability，and reduce postoperative pain. This article reviews the action mechanism of dexmedetomidine and the effect of dexmedetomidine on perioperative analgesia.

Key words: dexmedetomidine, perioperative, analgesic

中图分类号:

R969

刘璇, 滕金亮. 右美托咪定应用于围术期镇痛的研究进展[J]. 神经药理学报, DOI: 10.3969/j.issn.2095-1396.2019.06.009.

LIU Xuan, TENG Jin-liang. Effect of Dexmedetomidine on Perioperative Analgesia[J]. Acta Neuropharmacologica, DOI: 10.3969/j.issn.2095-1396.2019.06.009.

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