从姜黄素的代谢特点探讨姜黄素与胡椒碱的联合应用

doi:10.3969/j.issn.2095-1396.2019.06.010

摘要/Abstract

摘要：

姜黄素为一种黄色的天然酚类物质，具有抗肿瘤、抗氧化、抗炎及抗纤维化等药理作用，但其较低的生物利用度一直限制着姜黄素的开发利用。胡椒碱为桂皮酞胺类生物碱，具有良好的安全性，可通过抑制多种药物代谢酶和转运蛋白，增加姜黄素的生物利用度，进而增加其在多方面的药理作用。利用新制剂技术将姜黄素与胡椒碱共同包载于特殊的载体材料中可赋予药物新的特性，如：增加溶解度、提高稳定性以及赋予药物靶向性等，从而可进一步增加姜黄素的治疗效果。该文旨在简述姜黄素的分子特性及代谢特点，从代谢角度探讨胡椒碱增加其药理作用的机制，并综述两者联用的研究现状，从而为今后的科学研究提供参考依据。

关键词: 姜黄素, 胡椒碱, 联合用药, 生物利用度

Abstract:

Curcumin is a yellow acid phenolic substance with anti-tumor，anti-oxidation， anti-inflammatory and anti-fibrosis pharmacological effects，but its low bioavailability has always limited the development and utilization of curcumin. Piperine and cinnamolphthalein alkaloids have good safety，and can increase the bioavailability of curcumin by inhibiting multiple drug metabolic enzymes and transporters，thus increasing its pharmacological effects in many aspects. Using new preparation technology to encapsulate curcumin and piperine in special carrier materials can endow drugs with new properties，such as increased solubility，improved stability and drug targeting，so as to further increase the therapeutic effect of curcumin.The aim of this paper is to summarize the molecular and metabolic characteristics of curcumin，to discuss the mechanism of piperine increasing its pharmacological action from the metabolic perspective， and to summarize the research status of combined use of curcumin and piperine，so as to provide reference for future scientific research.

Key words: curcumin, piperine, combination therapy, bioavailability

中图分类号:

R964

梁宇飞, 张欣欣, 赵丽艳, 等. 从姜黄素的代谢特点探讨姜黄素与胡椒碱的联合应用[J]. 神经药理学报, DOI: 10.3969/j.issn.2095-1396.2019.06.010.

LIANG Yu-fei，ZHANG Xin-xin，ZHAO Li-yan，et al. Discussed the Application of Curcumin Combined with Piperine Based on the Metabolic Characteristics of Curcumin[J]. Acta Neuropharmacologica, DOI: 10.3969/j.issn.2095-1396.2019.06.010.

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