神经药理学报 ›› 2017, Vol. 7 ›› Issue (3): 21-32.DOI: 10.3969/j.issn.2095-1396.2017.03.004
黄茜,孙明丽,李腾飞,王永祥
出版日期:
2017-06-26
发布日期:
2017-12-01
通讯作者:
王永祥,教授;研究方向:疼痛生物学和转化医学;Tel:+86-021-34204763,Email:yxwang@sjtu.edu.cn
作者简介:
黄茜,博士;研究方向:疼痛药理学;Tel:+86-021-34204772,Email:windysalad@hotmail.com
基金资助:
国家自然科学基金项目(No.81673403)
HUANG Qian,SUN Ming-li,LI Teng-fei,WANG Yong-xiang
Online:
2017-06-26
Published:
2017-12-01
Contact:
王永祥,教授;研究方向:疼痛生物学和转化医学;Tel:+86-021-34204763,Email:yxwang@sjtu.edu.cn
About author:
黄茜,博士;研究方向:疼痛药理学;Tel:+86-021-34204772,Email:windysalad@hotmail.com
Supported by:
国家自然科学基金项目(No.81673403)
摘要: 乌头属植物资源丰富、药用历史悠久、在临床上应用广泛。二萜生物碱是乌头属植物的主要药理活性成分,按结构可分为C-18 型、C-19 型、C-20 型和双二萜生物碱,具有抗炎、镇痛、抗肿瘤等活性。本文旨在综述临床中广泛使用的乌头属药物中几种主要二萜生物碱,包括草乌甲素(C-19 型)、雪上一枝蒿甲素(C-20 型)、高乌甲素(C-18 型)及乌头碱(C-19 型)的镇痛作用和机制的研究进展,以及乌头炮制的药理学依据。草乌甲素、雪上一枝蒿甲素、高乌甲素和乌头碱在多种疼痛模型和临床研究中均表现出良好的镇痛作用,其镇痛作用系通过Gs/cAMP/PKA/p38β/CREB 信号通路,刺激脊髓背角的小胶质细胞释放强啡肽,随后作用于神经突触后膜神经元上的κ- 阿片受体而产生。乌头碱经炮制生成苯甲酰乌头原碱,毒性降低,治疗指数增加。此外,多种乌头属二萜生物碱和乌头提取物均不产生镇痛耐受作用,并能有效抑制吗啡的镇痛耐受,亦与它们的镇痛作用机制有关。
中图分类号:
黄茜,孙明丽,李腾飞,王永祥. 乌头生物碱镇痛作用及机制研究进展[J]. 神经药理学报, 2017, 7(3): 21-32.
HUANG Qian,SUN Ming-li,LI Teng-fei,WANG Yong-xiang. Research Progress on Mechanisms Underlying Aconitines Analgesia[J]. Acta Neuropharmacologica, 2017, 7(3): 21-32.
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